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Updated: Feb 10, 2026
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Murine Corneal Transplantation: A Model to Study the Most Common Form of Solid Organ Transplantation
Published on: November 17, 2014
10.2K
Hepatitis C: Current Controversies and Future Potential in Solid Organ Transplantation
Lucy Somerville1, Karen Doucette2
1Department of Medicine, Division of Infectious Diseases, University of Alberta, CSB 1-139, 11350 83 Avenue, Edmonton, AB, T6G 2G3, Canada.
Current Infectious Disease Reports
|May 24, 2018
Summary
Hepatitis C virus (HCV) infection is now curable in organ transplant recipients with direct-acting antiviral (DAA) agents. Organs from HCV-infected donors can expand the donor pool, with recipients treated post-transplant.
Area of Science:
- Hepatology
- Transplant Surgery
- Infectious Diseases
Background:
- Hepatitis C virus (HCV) historically posed significant challenges in organ transplantation.
- Outcomes for transplant recipients with HCV were often poorer due to limited treatment options.
Purpose of the Study:
- To review the evolving landscape of HCV in organ transplantation.
- To focus on controversies and future directions with direct-acting antiviral (DAA) agents.
Main Methods:
- Review of current literature on HCV treatment in transplant recipients.
- Analysis of outcomes data with direct-acting antiviral (DAA) therapy.
Main Results:
- Direct-acting antiviral (DAA) therapy offers high cure rates, excellent tolerability, and safety in transplant recipients.
- HCV is no longer a contraindication for organ transplantation.
- Organs from HCV-viremic donors are increasingly utilized, expanding the donor pool with successful recipient treatment.
Conclusions:
- HCV is curable in virtually all organ transplant recipients using DAAs.
- The use of organs from HCV-infected donors is a viable strategy to increase organ availability.
- Optimal timing of DAA therapy and donor organ utilization remain areas for ongoing research.
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