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Motile Dendritic Cells Sense and Respond to Substrate Geometry

Amy C Bendell1, Nicholas Anderson1, Daniel Blumenthal2

  • 1Department of Chemical and Biomolecular Engineering, University of Pennsylvania, Philadelphia, PA, USA.

Annals of Biomedical Engineering
|May 24, 2018
PubMed
Summary

Dendritic cell (DC) migration speed increases on micropost arrays, indicating geometry, not stiffness, influences their movement. This involves myosin contractility and integrin signaling, suggesting filopodia drive DC motility.

Keywords:
ActinDendritic cellsGeometryMechanosensingMigrationStiffnessmPAD

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