Related Experiment Video
Updated: Feb 10, 2026
Transthoracic Speckle Tracking Echocardiography for the Quantitative Assessment of Left Ventricular Myocardial Deformation
Published on: October 20, 2016
Value of three-dimensional speckle tracking echocardiography to assess left ventricular function in hyperuricemia
Xiaojie Zhang1, Qing Lu2, Zhuojun Zhang1
1Department of Rheumatology, Zhongshan Hospital, Fudan University, Shanghai, China.
Insights
Three-dimensional speckle tracking echocardiography (3D STE) reveals early left ventricular (LV) dysfunction in hyperuricemia patients. Global longitudinal strain (GLS) and global circumferential strain (GCS) are key indicators, with GCS correlating with serum uric acid levels.
Area of Science:
- Cardiology
- Medical Imaging
- Nephrology
Background:
- Hyperuricemia is associated with cardiovascular risks.
- Early detection of left ventricular (LV) dysfunction is crucial for managing hyperuricemia.
- Traditional echocardiography may not fully capture subtle LV functional changes.
Purpose of the Study:
- To evaluate the utility of three-dimensional speckle tracking echocardiography (3D STE) in assessing LV function in patients with hyperuricemia.
- To identify specific 3D STE parameters indicative of early LV dysfunction in this population.
- To explore the correlation between LV function parameters and serum uric acid levels.
Main Methods:
- A comparative study involving 40 hyperuricemia patients and 15 healthy controls.
- Acquisition and analysis of full-volume 3D STE images of the left ventricle.
- Measurement of LV ejection fraction, volumes, stroke volume (SV), global longitudinal strain (GLS), and global circumferential strain (GCS).
Main Results:
- Hyperuricemia patients showed significantly higher BMI, C-reactive protein, liver enzymes, BUN, and serum creatinine, with lower eGFR.
- Significantly decreased SV, GLS, and GCS were observed in hyperuricemia patients compared to controls.
- Global circumferential strain (GCS) demonstrated a significant correlation with serum uric acid levels, even after adjusting for confounders.
Conclusions:
- 3D STE is a valuable tool for detecting early-stage LV functional decline in hyperuricemia patients.
- GLS and GCS are reliable echocardiographic indicators of subclinical LV dysfunction in this cohort.
- The severity of LV dysfunction, particularly GCS, may be linked to serum uric acid levels.
Abstract:
To assess the value of three-dimensional speckle tracking echocardiography (3D STE) in evaluating the left ventricular (LV) function in hyperuricemia patients. We enrolled 15 healthy controls and 40 hyperuricemia patients and collected and analyzed full-volume 3D STE images of the left ventricle in the apical four-chamber heart view. Laboratory tests and 3D STE parameters, including left ventricular ejection fraction, left ventricular end-diastolic volume, left ventricular end-systolic volume, stroke volume (SV), global longitudinal strain (GLS), and global circumferential strain (GCS), were compared between hyperuricemia patients and healthy controls. Hyperuricemia patients exhibited higher body mass index (24.70 ± 2.9 vs. 21.83 ± 2.4 kg/m2, p = 0.001), C-reactive protein (5.82 ± 9.4 vs. 1.12 ± 1.8 g/L, p = 0.012), alanine transaminase (34.26 ± 26.6 vs. 17.60 ± 13.0 U/L, p = 0.011), aspartate transaminase (24.90 ± 11.3 vs. 17.70 ± 4.1 U/L, p = 0.001), blood urea nitrogen (5.11 ± 1.6 vs. 4.18 ± 0.6 mmol/L, p = 0.046), and serum creatinine (90.25 ± 14.6 vs. 77.93 ± 10.8 μmol/L, p = 0.006) levels, as well as a lower estimated glomerular filtration rate (87.87 ± 16.5 vs. 103.64 ± 11.3 mL/min/1.73m2, p = 0.002). The 3D STE parameters reflecting LV function, including SV (54.71 ± 9.6 vs. 61.92 ± 14.4 mL, p = 0.024), GLS (- 20.51 ± 4.0 vs. - 23.20 ± 4.0%, p = 0.019), and GCS (- 31.30 ± 5.0 vs. - 35.65 ± 2.5%, p = 0.000), were significantly decreased in hyperuricemia patients. Furthermore, GCS was significantly correlated with the serum uric acid (sUA) level even after adjustment of confounding variables like age, body mass index, and serum creatinine. 3D STE is a novel technique for recognizing the early decline in LV function, with GLS and GCS serving as reliable indicators, in hyperuricemia patients. Moreover, the degree of decline in LV function may be correlated with the sUA level in hyperuricemia patients.
Related Concept Videos
03:40Dimensional Analysis
Conversion Factors and Dimensional Analysis
The unit...
01:27Dimensional Analysis
In fluid mechanics, dimensional...
01:23Dimensional Analysis
Dimensional analysis allows us to analyze and compare physical quantities on a...
02:19Dimensional Analysis
01:24Nursing Process for Patient and Caregiver Teaching I: Assessment and Diagnosis
It is critical to determine the patient's learning needs during the assessment. Determination of learning needs compounds data...
01:20Imaging Studies for Cardiovascular System II:Types of Echocardiography
Types of Echocardiography
Transthoracic Echocardiography (TTE)
TTE is the most common type of echocardiogram which involves placing a transducer on the patient's chest, emitting sound waves to create heart images. TTE is invaluable for evaluating the heart's size, structure, and motion, making it particularly useful for...