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Diagnosing acute coronary syndrome or ACS begins with a thorough patient history. Notable symptoms include central, crushing chest pain radiating to the left arm, neck, jaw, or back, along with shortness of breath, sweating (diaphoresis), nausea, vomiting, dizziness, and palpitations.It is crucial to note any history of cardiac illnesses and assess risk factors, including age, gender, smoking, hypertension, diabetes, hyperlipidemia, and a sedentary lifestyle.During physical examination, vital...
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In this lesson, we delve into the role of ring conformation and its stability, which determines the spatial arrangement and, consequently, the molecular symmetry and stereoisomerism of cyclic compounds. 1,2-Dimethylcyclohexane is used as a case study to evaluate the possible number of stereoisomers. Here, given the multiple (n = 2) chiral centers, there are 2n = 4 possible configurations that lack a plane of symmetry, as the ring skeleton exists in a non-planar chair conformation. In addition,...
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A thermodynamic system with zero heat exchange and work is an isolated system. For these systems, the internal energy remains constant.
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Acute Coronary Syndrome (ACS) encompasses a spectrum of heart conditions caused by sudden obstruction of coronary arteries, typically resulting from the rupture of an atherosclerotic plaque and subsequent thrombus (blood clot) formation. This obstruction can lead to partial or complete blockage of blood flow, causing varying degrees of myocardial ischemia or infarction.ACS includes the following clinical entities:Unstable Angina (UA)Non-ST-Elevation Myocardial Infarction (NSTEMI)ST-Elevation...
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[Cyclic Cushings syndrome: a case study and overview].

Jana Kollerová, Ján Malina, Andrej Šteňo

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    Cyclic Cushing's syndrome presents diagnostic and treatment challenges due to fluctuating cortisol levels, potentially leading to underdiagnosis. This variant of Cushing's disease requires careful management and monitoring for accurate assessment of cure.

    Area of Science:

    • Endocrinology
    • Internal Medicine

    Background:

    • Cushing's syndrome and Cushing's disease are complex endocrine disorders.
    • Cyclic variations in cortisol production complicate diagnosis and treatment monitoring.

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