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Updated: Feb 10, 2026

Human Neuroendocrine Tumor Cell Lines as a Three-Dimensional Model for the Study of Human Neuroendocrine Tumor Therapy
Published on: August 14, 2012
[Endoscopic treatment of rectal neuroendocrine tumors: multicentre study in Peru]
Fernando Palacios Salas1, Edson Guzmán Calderón2, Estefanía Liza Baca3
1Hospital Nacional Edgardo Rebagliati Martins. Lima, Perú; Clínica Delgado. Lima, Perú; Clínica Internacional. Lima, Perú.
Introduction:
The incidental detection of rectal neuroendocrine tumors (NET) has increased but there is no proper consensus about treatment.
Objective:
Evaluate the efficacy and safety of endoscopic treatment for rectal NET less than 20 mm, with emphasis in "standardized treatment".
Material And Methods:
From January 2012 to April 2016, we included patients with rectal NET less than 20 mm resected by conventional EMR, EMR-B and ESD. We considered as "standardized treatment" the one that has precise indication and technical rigor (EMR-B for lesions ≤ 10 mm and ESD for lesions between 11 and 20 mm). We evaluate complete resection rates and incidence of complications.
Results:
23 patients with 23 rectal NET were included. The mean age was 52.96 ± 12.44 years. The mean tumor diameter was 8.8 ± 3.4 mm. The complete resection rates by conventional EMR, EMR-Band ESD were 50 (3/6), 92.8 (13/14) and 100% (3/3), respectively; while by standardized and conventional treatment were 100 (14/14) and 55.5% (5/9), respectively. Complications occurred in 4 cases (17.4%), bleeding in 2 and perforation in 2, all of them solved by endoscopy.
Conclusions:
Endoscopic treatment by EMR-B and ESD is efficacious and safe for rectal NET ≤ 20 mm. Standardized treatment improve the efficacy of endoscopic treatment.
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