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Dietary Magnesium and Chronic Disease
1Research Nutritionist Consultant, ORCID ID 0000-0001-9557-4792, Grand Forks, ND.
Advances in Chronic Kidney Disease
|May 26, 2018
Summary
Marginal magnesium deficiency, common in adults, may increase chronic inflammation and disease risk. Supplementation may reduce inflammation and lower the risk of chronic conditions like heart disease and diabetes.
Area of Science:
- Nutrition Science
- Immunology
- Chronic Disease Epidemiology
Background:
- Subclinical magnesium (Mg) deficiency is prevalent, affecting 50%-99% of adult requirements.
- This marginal Mg intake is typically asymptomatic but primes immune cells for inflammatory responses.
- Chronic inflammation and oxidative stress are linked to numerous non-communicable diseases.
Purpose of the Study:
- To investigate the association between dietary magnesium intake and chronic inflammation.
- To explore the role of magnesium in modulating inflammatory markers and chronic disease risk.
- To synthesize evidence on magnesium's impact on inflammatory and oxidative stress pathways.
Main Methods:
- Analysis of human studies examining dietary magnesium intake and serum C-reactive protein (CRP) levels.
- Review of animal studies on the effects of subclinical magnesium deficiency on phagocytic cells.
- Synthesis of findings from meta-analyses and systematic reviews on magnesium and chronic disease incidence.
Main Results:
- Dietary magnesium intake is inversely correlated with serum/plasma C-reactive protein (CRP).
- Individuals with low magnesium intake show higher likelihood of elevated CRP (≥3.0 mg/L), indicating inflammation.
- Magnesium supplementation reduced elevated CRP levels in individuals with chronic diseases.
Conclusions:
- Dietary magnesium plays a crucial role in mitigating chronic inflammation and oxidative stress.
- Adequate magnesium intake may reduce the risk of chronic diseases, including hypertension, heart disease, stroke, metabolic syndrome, diabetes, and colorectal cancer.
- Addressing marginal magnesium deficiency is vital for public health and chronic disease prevention.
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