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Updated: Feb 10, 2026

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Who does TORC2 talk to?

Jianling Xie1, Xuemin Wang1,2, Christopher G Proud3,2

  • 1Nutrition and Metabolism, South Australian Health and Medical Research Institute, North Terrace, Adelaide, South Australia 5000, Australia.

The Biochemical Journal
|May 26, 2018
PubMed
Summary
This summary is machine-generated.

The target of rapamycin complex 2 (TORC2) is a key protein kinase regulating cell metabolism, gene transcription, and the cytoskeleton. Understanding TORC2

Keywords:
mechanistic target of rapamycinpost-translational modificationtranslation

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Area of Science:

  • Cellular Biology
  • Molecular Biology
  • Biochemistry

Background:

  • The target of rapamycin (TOR) is a crucial protein kinase involved in cellular signaling.
  • TOR functions through two distinct complexes: TOR complex 1 (TORC1) and TOR complex 2 (TORC2).
  • TOR dysregulation is implicated in various diseases.

Purpose of the Study:

  • To review recent advances in understanding mammalian TOR complex 2 (mTORC2).
  • To elucidate the structure, regulation, and substrates of mTORC2.
  • To connect mTORC2 signaling to the control of essential cell functions.

Main Methods:

  • Literature review of recent research on mTORC2.
  • Analysis of studies detailing mTORC2 composition, control, and substrates.
  • Synthesis of findings on mTORC2's role in cellular physiology.

Main Results:

  • mTORC2 regulates critical cellular processes including lipogenesis and glucose transport.
  • mTORC2 influences gene transcription and cytoskeletal organization.
  • mTORC2 impacts the activity of other protein kinases.

Conclusions:

  • mTORC2 is a vital regulator of cell metabolism and function.
  • Further understanding of mTORC2 pathways is crucial for disease research.
  • mTORC2's diverse roles highlight its significance in cellular homeostasis.