Related Experiment Video
Updated: Feb 10, 2026
06:33
Author Spotlight: Streamlined Brain and Skull Modeling for Enhanced Neurosurgical Planning in NHP Research
Published on: February 9, 2024
1.8K
Cannabidiol effects on prepulse inhibition in nonhuman primates
Patricia G Saletti1,2, Carlos Tomaz2,3
1Albert Einstein College of Medicine, Rose F. Kennedy Center, Rm 310, 1410 Pelham Parkway South, Bronx, NY 10461, USA.
Reviews in the Neurosciences
|May 26, 2018
Summary
Cannabidiol (CBD) shows promise for treating neurological disorders like schizophrenia by improving sensorimotor gating. The prepulse inhibition (PPI) test effectively screens CBD
Area of Science:
- Neuroscience
- Psychopharmacology
- Behavioral Science
Background:
- Prepulse inhibition (PPI) of the acoustic startle reflex is a key measure of sensorimotor gating.
- Disruptions in sensorimotor gating are implicated in neuropsychiatric disorders, notably schizophrenia.
- PPI paradigms offer a valuable tool for screening potential therapeutic agents for these conditions.
Purpose of the Study:
- To review the utility of the PPI paradigm in evaluating the therapeutic effects of cannabidiol (CBD).
- To assess CBD's impact on PPI responses in animal models relevant to neuropsychiatric disorders.
Main Methods:
- Literature review focusing on studies examining CBD's effects on PPI.
- Analysis of data from animal models, including rodents and nonhuman primates.
- Examination of CBD's efficacy in N-methyl-D-aspartate receptor antagonist models of schizophrenia.
Main Results:
- Cannabidiol (CBD) has demonstrated the ability to modulate PPI.
- These modulatory effects were observed in both rodent and nonhuman primate models.
- CBD's influence on PPI was evident in N-methyl-D-aspartate receptor antagonist-induced models of schizophrenia.
Conclusions:
- Cannabidiol (CBD) shows potential as a therapeutic agent for neurological disorders characterized by sensorimotor gating deficits, such as schizophrenia.
- The PPI paradigm serves as a practical and effective method for assessing the efficacy of CBD as a potential therapeutic drug.
Related Concept Videos
00:46Feedback Inhibition
57.3K
Biochemical reactions are occurring constantly in cells, converting starting substances to different products, usually with the help of enzymes that speed the reactions. Without enzymes, it would take far too long for most reactions to occur to be useful to the cell!
57.3K
02:19Buffer Effectiveness
55.5K
Buffer solutions do not have an unlimited capacity to keep the pH relatively constant . Instead, the ability of a buffer solution to resist changes in pH relies on the presence of appreciable amounts of its conjugate weak acid-base pair. When enough strong acid or base is added to substantially lower the concentration of either member of the buffer pair, the buffering action within the solution is compromised.
The buffer capacity is the amount of acid or base that can be added to a given volume...
The buffer capacity is the amount of acid or base that can be added to a given volume...
55.5K
01:30Enzyme Inhibition
92.7K
Inhibitors are molecules that reduce enzyme activity by binding to the enzyme. In a normally functioning cell, enzymes are regulated by a variety of inhibitors. Drugs and other toxins can also inhibit enzymes. Some inhibitors bind to the enzyme’s active site, while others inhibit enzymatic activity by binding to other sites on the protein structure.
92.7K
02:34Inhibition of Cdk Activity
6.0K
The orderly progression of the cell cycle depends on the activation of Cdk protein by binding to its cyclin partner. However, the cell cycle must be restricted when undergoing abnormal changes. Most cancers correlate to the deregulated cell cycle, and since Cdks are a central component of the cell cycle, Cdk inhibitors are extensively studied to develop anticancer agents. For instance, cyclin D associates with several Cdks, such as Cdk 4/6, to form an active complex. The cyclin D-Cdk4/6 complex...
6.0K
03:26Framing Effects
8.0K
Information is everywhere and its presentation—such as how and when items are presented—can impact our perceptions and decisions surrounding the info. This broad concept umbrellas framing effects—influences that occur due to the way information is framed in its appearance, whether it’s purely the order or the specific wording of a message. Let’s take a look at numerous ways in which two versions of something can objectively say the same thing, yet we respond in...
8.0K
02:59Biological Effects of Radiation
18.0K
All radioactive nuclides emit high-energy particles or electromagnetic waves. When this radiation encounters living cells, it can cause heating, break chemical bonds, or ionize molecules. The most serious biological damage results when these radioactive emissions fragment or ionize molecules. For example, α and β particles emitted from nuclear decay reactions possess much higher energies than ordinary chemical bond energies. When these particles strike and penetrate matter, they...
18.0K