Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Speciation Rates01:07

Speciation Rates

22.9K
Overview
22.9K
Genetics of Speciation02:16

Genetics of Speciation

21.8K
Speciation is the evolutionary process resulting in the formation of new, distinct species—groups of reproductively isolated populations.
21.8K
Gene Flow02:39

Gene Flow

38.0K
Gene flow is the transfer of genes among populations, resulting from either the dispersal of gametes or from the migration of individuals.
38.0K
Phase Transitions02:31

Phase Transitions

23.3K
Whether solid, liquid, or gas, a substance's state depends on the order and arrangement of its particles (atoms, molecules, or ions). Particles in the solid pack closely together, generally in a pattern. The particles vibrate about their fixed positions but do not move or squeeze past their neighbors. In liquids, although the particles are closely spaced, they are randomly arranged. The position of the particles are not fixed—that is, they are free to move past their neighbors to...
23.3K
Gene Families01:57

Gene Families

10.0K
Gene families consist of groups of genes proposed to have originated from a common ancestor. Typically these arise through events in which a gene or genes are mistakenly duplicated during cell division. Unlike their parent genes (which are subject to selection pressure to maintain function), these gene copies do not need to preserve their sequences and may evolve at a relatively faster rate.
Occasionally these regions can be adapted to take on new roles within the organism, becoming novel genes...
10.0K
Mutation, Gene Flow, and Genetic Drift01:09

Mutation, Gene Flow, and Genetic Drift

64.5K
In a population that is not at Hardy-Weinberg equilibrium, the frequency of alleles changes over time. Therefore, any deviations from the five conditions of Hardy-Weinberg equilibrium can alter the genetic variation of a given population. Conditions that change the genetic variability of a population include mutations, natural selection, non-random mating, gene flow, and genetic drift (small population size).
64.5K

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Transitions in exercise motive profiles and their association with physical activity adherence among low-active middle-aged adults: An exploratory ancillary analysis.

Psychology of sport and exercise·2026
Same author

Larval Genomics as a Viable, Fisheries-Independent Tool for Investigating Population Structure in Tropical Pacific Tunas.

Molecular ecology·2026
Same author

Chromosomal Fusions Promote Speciation in Subterranean Blind Mole Rats.

Molecular ecology·2026
Same author

Genre-Specific Gaming Addiction and Flourishing in Adolescents: Cross-Sectional Survey Study.

Journal of medical Internet research·2026
Same author

Climate and species traits give rise to complex phenological dynamics.

Ecology·2026
Same author

Admixture in a butterfly species complex creates a genomic mosaic of ancestry with distinct histories for different chromosomes.

bioRxiv : the preprint server for biology·2025

Related Experiment Video

Updated: Feb 10, 2026

Author Spotlight: Advancing Chromatin Research and Overcoming Limitations with a High-Enrichment Locus-Specific Chromatin Isolation Protocol
10:33

Author Spotlight: Advancing Chromatin Research and Overcoming Limitations with a High-Enrichment Locus-Specific Chromatin Isolation Protocol

Published on: November 17, 2023

1.7K

Transitions from Single- to Multi-Locus Processes during Speciation with Gene Flow.

Martin P Schilling1, Sean P Mullen2, Marcus Kronforst3

  • 1Department of Ecology and Evolutionary Biology, University of Colorado, Boulder, CO 80309, USA. schimar@gmail.com.

Genes
|May 26, 2018
PubMed
Summary
This summary is machine-generated.

Stronger selection and lower migration facilitate multi-locus genetic coupling during speciation, creating barriers to gene flow. This process, observed in simulations and Heliconius butterflies, drives rapid genome-wide transitions.

Keywords:
Heliconiuscouplinggene flownonlinear transitionsparapatrypopulation genomicssimulation modelsympatry

More Related Videos

Multi-target Parallel Processing Approach for Gene-to-structure Determination of the Influenza Polymerase PB2 Subunit
22:10

Multi-target Parallel Processing Approach for Gene-to-structure Determination of the Influenza Polymerase PB2 Subunit

Published on: June 28, 2013

13.7K
Rapid Assembly of Multi-Gene Constructs using Modular Golden Gate Cloning
08:31

Rapid Assembly of Multi-Gene Constructs using Modular Golden Gate Cloning

Published on: February 5, 2021

15.0K

Related Experiment Videos

Last Updated: Feb 10, 2026

Author Spotlight: Advancing Chromatin Research and Overcoming Limitations with a High-Enrichment Locus-Specific Chromatin Isolation Protocol
10:33

Author Spotlight: Advancing Chromatin Research and Overcoming Limitations with a High-Enrichment Locus-Specific Chromatin Isolation Protocol

Published on: November 17, 2023

1.7K
Multi-target Parallel Processing Approach for Gene-to-structure Determination of the Influenza Polymerase PB2 Subunit
22:10

Multi-target Parallel Processing Approach for Gene-to-structure Determination of the Influenza Polymerase PB2 Subunit

Published on: June 28, 2013

13.7K
Rapid Assembly of Multi-Gene Constructs using Modular Golden Gate Cloning
08:31

Rapid Assembly of Multi-Gene Constructs using Modular Golden Gate Cloning

Published on: February 5, 2021

15.0K

Area of Science:

  • Evolutionary Biology
  • Genetics
  • Speciation Research

Background:

  • Speciation with gene flow involves transitions from single-locus to multi-locus genetic processes.
  • Strong coupling of multiple loci can establish barriers to gene flow, a key aspect of speciation.
  • Empirical testing requires advanced quantitative approaches and building upon existing theoretical frameworks.

Purpose of the Study:

  • To investigate how selected and neutral genetic sites differ in their requirements for transitions during speciation.
  • To explore the conditions under which transitions from single-locus to multi-locus processes occur during speciation with gene flow.
  • To examine the role of linkage disequilibrium (LD) and coupling statistics in speciation.

Main Methods:

  • Simulated genomes under various scenarios of gene flow and divergent selection, incorporating neutral sites and coupling statistics.
  • Extended previous theoretical work by adding neutral sites and coupling statistics to simulations.
  • Analyzed published genome resequencing data from Heliconius butterflies to compare empirical patterns with simulation results.

Main Results:

  • Increased selection strength and decreased migration facilitated divergence at selected sites, leading to increased linkage disequilibrium (LD) earlier than at neutral sites.
  • Low rates of gene flow effectively prevented differentiation at neutral sites, while strong coupling among selected sites eventually reduced gene flow at neutral sites.
  • Empirical data from Heliconius butterflies showed that fixation index (FST) outliers and allele-frequency outliers exhibited stronger within-deme LD than the genomic background.

Conclusions:

  • Selection drives rapid, genome-wide transitions to multi-locus coupling during speciation.
  • The interaction between divergence and gene flow is crucial along the speciation continuum.
  • Within-deme LD patterns provide insights into the strength of coupling among barrier loci and vary across genomic regions and taxa.