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Disrupted interhemispheric functional connectivity in chronic insomnia disorder: a resting-state fMRI study
Fuqing Zhou1,2, Yanlin Zhao1,2, Muhua Huang1,2
1Department of Radiology, The First Affiliated Hospital, Nanchang University, Nanchang, China.
Neuropsychiatric Disease and Treatment
|May 26, 2018
Summary
Chronic insomnia disorder (CID) is linked to reduced interhemispheric communication in the brain, specifically in the occipital and temporal regions. These functional changes occur without significant structural alterations in white or gray matter.
Area of Science:
- Neuroscience
- Brain Imaging
- Sleep Medicine
Background:
- Chronic insomnia disorder (CID) is associated with known cerebral structural and activity abnormalities.
- Interhemispheric integration, crucial for brain coordination, remains poorly understood in CID.
- Functional homotopy is a key aspect of intrinsic functional architecture for interhemispheric coordination.
Purpose of the Study:
- To investigate interhemispheric integration in patients with chronic insomnia disorder.
- To analyze patterns of intrinsic functional connectivity between brain hemispheres in CID.
- To explore the relationship between functional connectivity and clinical measures in CID.
Main Methods:
- Utilized voxel-mirrored homotopic connectivity (VMHC) to analyze functional connectivity.
- Examined interhemispheric intrinsic functional connectivity patterns in 29 patients with CID.
- Compared connectivity patterns between CID patients and control subjects.
Main Results:
- Reduced homotopic connectivity was found in the middle occipital/posterior middle temporal gyrus in CID patients.
- Distinct insomnia-related heterotopic connectivity patterns were observed in the right and left hemispheres.
- Connectivity coefficients in the middle occipital/posterior middle temporal gyrus network correlated with anxiety levels in CID patients.
Conclusions:
- Disruptions in interhemispheric communication architecture are evident in CID.
- These functional changes occur despite the absence of detectable microstructural or local morphometric changes in white and gray matter.
- VMHC analysis reveals functional alterations in interhemispheric communication in CID, independent of structural changes.
Keywords:
chronic primary insomniahomotopic connectivityinterhemispheric integrationresting-state fMRIsleep disordersvoxel-mirrored homotopic connectivityMore Related Videos
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