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07:55
Establishment of a Primary Culture of Patient-derived Soft Tissue Sarcoma
Published on: April 11, 2018
15.2K
Long-Term Outcome After Surgery for a Localized Retroperitoneal Soft Tissue Sarcoma in Elderly Patients: Results from
I Sourrouille1, R Macovei1, M Faron1
1Department of Surgical Oncology, Gustave Roussy Cancer Campus, Villejuif Cedex, France.
Annals of Surgical Oncology
|May 26, 2018
Summary
Curative surgery for retroperitoneal sarcoma (RPS) in elderly patients (≥70 years) is feasible, offering prolonged survival despite higher risks. Careful patient selection is crucial to minimize postoperative mortality and morbidity.
Area of Science:
- Surgical Oncology
- Geriatric Surgery
- Sarcoma Research
Background:
- Retroperitoneal sarcomas (RPS) present unique challenges, particularly in elderly populations.
- Evaluating surgical outcomes in patients aged 70 years and older is critical for optimizing treatment strategies.
Purpose of the Study:
- To assess the short- and long-term results of curative surgery for retroperitoneal sarcoma in elderly patients.
- To identify factors influencing survival and recurrence in this specific demographic.
Main Methods:
- Retrospective analysis of patients with nonmetastatic RPS treated between 1994 and 2015.
- Inclusion criteria: patients aged 70 years and older undergoing curative surgery.
Main Results:
- Sixty elderly patients (20%) aged ≥70 years underwent surgery; median age 74 years. Median tumor size was 24 cm.
- Postoperative mortality was 8%, severe morbidity 32%. 5-year overall survival was 90%.
- Independent predictors of locoregional relapse included reoperation and postoperative morbidity.
Conclusions:
- Curative surgery for retroperitoneal sarcoma is achievable in selected elderly patients, leading to extended survival.
- Higher mortality and morbidity rates are observed compared to younger cohorts.
- Future research should refine patient selection criteria to reduce surgical complications.
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