[Screening for effective antibiotics in chronic suppurative otitis media]

Area of Science:

• Otolaryngology
• Infectious Diseases
• Pharmacology

Background:

• Otitis media requires effective antibiotic strategies for treatment.
• Rational clinical application of antibiotics is crucial for managing middle ear infections.

Purpose of the Study:

• To explore methods for screening effective antibiotics in the active stage of otitis media.
• To provide a basis for rational clinical antibiotic use in otitis media.

Main Methods:

• Analysis of clinical data from 198 otitis media patients.
• Bacterial culture and drug sensitivity testing of middle ear secretions.
• Screening of first and second-line drugs based on efficacy and ototoxicity.

Main Results:

• Coagulase-negative Staphylococcus (20.34%) was sensitive to linezolid, vancomycin, cefuroxime, levofloxacin, SMZ-TMP, and rifampin.
• Pseudomonas aeruginosa (16.95%) showed sensitivity to meropenem, imipenem, ceftazidime, amikacin, and piperacillin.
• Staphylococcus aureus (14.69%) was sensitive to linezolid, vancomycin, oxacilin, gentamycin, levofloxacin, ciprofloxacin, and moxifloxacin. Experienced-based first-line oral antibiotics included cefuroxime and moxifloxacin, with levofloxacin eardrops and ceftazidime as second-line options.

Conclusions:

• Antibiotics selected via bacterial culture and drug sensitivity testing are effective in otitis media.
• This targeted approach helps reduce post-surgical infection complications.