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Sample Preparation for Endopeptidomic Analysis in Human Cerebrospinal Fluid
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Sample Preparation for Endopeptidomic Analysis in Human Cerebrospinal Fluid

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[The diversity analysis of spontaneous cerebrospinal fluid otorrhea between young children and adults]

J Liu1, L Y Mei1, C F He1

  • 1Department of Otolaryngology Head and Neck Surgery，Xiangya Hospital,Central South University，Changsha，410008，China.

Lin Chuang Er Bi Yan Hou Tou Jing Wai Ke Za Zhi = Journal of Clinical Otorhinolaryngology Head and Neck Surgery
|May 26, 2018
PubMed

Insights

Spontaneous cerebrospinal fluid (CSF) otorrhea presents differently in children and adults. High-resolution CT scans are crucial for identifying leak sites and guiding surgical approach selection, particularly in adults.

Area of Science:

  • Otolaryngology
  • Neurosurgery
  • Radiology

Context:

  • Spontaneous cerebrospinal fluid (CSF) otorrhea is a rare condition involving leakage of CSF from the inner ear.
  • Clinical manifestations, diagnostic imaging, and surgical management can differ between pediatric and adult patients.

Purpose:

  • To compare the clinical features, CT findings, leakage locations, and surgical outcomes of spontaneous CSF otorrhea in young children versus adults.
  • To evaluate the effectiveness of the transmastoid approach for treating CSF otorrhea in both age groups.

Summary:

  • A retrospective study of 6 patients (4 adults, 2 children) with spontaneous CSF otorrhea treated via transmastoid approach was conducted.
  • Adults had defects in the tegmen mastoideum, tegmen tympani, or at the sinus-meningeal angle without inner ear abnormalities.
  • Children presented with congenital inner ear anomalies and defects in the footplate or fenestra vestibule.
  • Successful repair was achieved in most cases, with one adult requiring multiple revisions.
  • HRCT of the temporal bone is vital for pre-operative assessment, especially in adults, to precisely locate all defects for optimal surgical planning.

Impact:

  • Highlights the distinct clinical presentations and anatomical defect locations of CSF otorrhea in pediatric versus adult populations.
  • Emphasizes the critical role of high-resolution CT imaging in pre-operative evaluation for successful surgical intervention.
  • Provides insights into surgical strategy selection based on accurate identification of CSF leak sites and number of defects.

Keywords:
Mondini dysplasiacerebrospinal fluid otorrheatemporal bonedefect

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