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Updated: Feb 10, 2026

Organ Ischemia-Reperfusion Injury by Simulating Hemodynamic Changes in Rat Liver Transplant Model
Published on: March 6, 2021
[Protective effect of exosome on organs after ischemia-reperfusion injury]
Jinglan Huang1, Bingyao Kang2, Yi Qu1
1Department of Pediatrics, Key Laboratory of Obstetric & Gynecologic and Pediatric Diseases and Birth Defects of Ministry of Education, West China Second Hospital, Sichuan University, Chengdu Sichuan, 610041, P.R.China.
Objective:
To investigate the protective effect of the exosome on the organ damage induced by ische-mia-reperfusion (I/R) so as to provide a new way for the treatment of I/R damage.
Methods:
The literature related to the treatment of I/R damage was reviewed and analyzed.
Results:
The exosome volume is small and it is present in blood, cerebrospinal fluid, and urine, which has the function to cross the blood-brain barrier, and protect the heart, brain and other organs after I/R damage.
Conclusion:
Exosome is a new material for the treatment of I/R organ injury, and it is important to understand the protective effect and possible mechanism.
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