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Updated: Feb 10, 2026

Palladium N-Heterocyclic Carbene Complexes: Synthesis from Benzimidazolium Salts and Catalytic Activity in Carbon-carbon Bond-forming Reactions
Published on: July 30, 2017
Palladium-Catalyzed Benzylic Phosphorylation of Diarylmethyl Carbonates
Akihiro Matsude1, Koji Hirano1, Masahiro Miura1
1Department of Applied Chemistry, Graduate School of Engineering , Osaka University , Suita , Osaka 565-0871 , Japan.
Abstract:
A palladium-catalyzed benzylic substitution of tert-butyl diarylmethyl carbonates with a pinacol-derived H-phosphonate proceeds to deliver the corresponding benzylic phosphorylated products in good yields. Moreover, the asymmetric synthesis is possible via a Pd/( Rp, R'p)-( S)-Mandyphos-catalyzed kinetic resolution-DYKAT (dynamic kinetic asymmetric transformation) sequence, and optically active α-chiral diarylmethylphosphonates are obtained with synthetically useful yields and enantiomeric ratios (up to 50% and 92:8 er).
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