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Recent advances in electrospun for drug delivery purpose
Mengyao Liu1, Yanan Zhang1, Siyu Sun1
1a Department of Pharmaceutics, College of Pharmacy , Shandong University , Jinan , China.
Journal of Drug Targeting
|May 26, 2018
Summary
Electrospun nanofibers offer advanced drug delivery systems (DDSs), improving the efficacy of various drugs. This technology shows great promise for future pharmaceutical applications.
Area of Science:
- Materials Science
- Nanotechnology
- Pharmaceutical Sciences
Background:
- Electrospinning is an advanced fiber production technology with significant merits for novel drug delivery systems (DDSs).
- This technique fabricates fibers on the micrometer to nanometer scale, attracting substantial scientific interest.
- Controlling drug release for treating illnesses is influenced by polymer selection, electrospinning processes, and parameters.
Purpose of the Study:
- To review the application of electrospun nanofibers in drug delivery systems.
- To discuss the in vivo and in vitro evaluations of electrospun nanofibers.
- To explore the prospects and challenges of designing drug-loaded electrospun nanofibers.
Main Methods:
- Fabrication of nanofibers using electrospinning and electrospraying techniques.
- Evaluation of drug release kinetics and bioactivity in vitro and in vivo.
- Investigation of pharmacokinetic profiles of drugs delivered via electrospun systems.
Main Results:
- Electrospun nanofibers demonstrate improved bioactivity for diverse drugs, including water-insoluble, soluble, anticancer, and antibacterial agents, as well as genetic materials.
- The technology allows for precise control over drug release profiles through careful selection of polymers and process parameters.
- Electrospinning has been successfully utilized to design advanced DDS, investigate pharmacokinetics, and enhance drug efficacy.
Conclusions:
- Electrospun nanofibers represent a versatile platform for developing next-generation drug delivery systems.
- The technology offers significant advantages in improving drug bioavailability and therapeutic outcomes.
- Further research into the prospects and challenges is crucial for optimizing drug-loaded electrospun nanofiber design.
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