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Genetic polymorphism in RANK is associated with mandibular size
Erika Calvano Küchler1, Mariele Andrade do Nascimento1, Mirian Aiko Nakane Matsumoto2
1a Department of Pediatric Dentistry, School of Dentistry of RibeirãoPreto , University of São Paulo , RibeirãoPreto , Brazil.
Journal of Orthodontics
|May 26, 2018
Summary
Genetic variations in RANK influence mandibular size. This study found a specific RANK polymorphism (rs3826620) significantly associated with increased mandibular dimensions in humans, impacting craniofacial measurements.
Area of Science:
- Genetics
- Orthodontics
- Anthropology
Background:
- Craniofacial development is influenced by genetic factors.
- The RANK, RANKL, and OPG gene pathways play roles in bone remodeling and development.
- Understanding genetic associations with craniofacial dimensions is crucial for personalized medicine and orthodontics.
Purpose of the Study:
- To investigate the association between genetic polymorphisms in RANK, RANKL, and OPG genes and maxillary and mandibular dimensions.
- To identify specific genetic variants that may influence craniofacial morphology.
Main Methods:
- Saliva DNA was analyzed for specific polymorphisms (rs3826620 in RANK, rs9594738 in RANKL, rs2073618 in OPG) using real-time PCR.
- Lateral cephalograms were used to measure four key craniofacial dimensions (Co-Gn, GoPg, Co-Go, PTM-A).
- Statistical analyses included ANOVA and multivariate regression, adjusted for age and gender.
Main Results:
- A significant association was found between a RANK gene polymorphism (rs3826620) and increased mandibular measurements (Go-Pg and Co-Gn).
- The polymorphism in RANK was linked to a higher Go-Pg measurement (p=0.039) in initial analysis.
- Multivariate analysis confirmed the association of the RANK polymorphism with Go-Pg (p=0.017) and Co-Gn (p=0.043).
Conclusions:
- The rs3826620 polymorphism in the RANK gene is associated with mandibular size.
- These findings suggest a genetic basis for variations in mandibular dimensions, potentially impacting craniofacial development.
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