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Establishment of Viral Infection and Analysis of Host-Virus Interaction in Drosophila Melanogaster
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Monkey viral pathology in the Sukhum colony and modeling human viral infections

Boris A Lapin1, Zinaida V Shevtsova2

  • 1Research Institute of Medical Primatology, Sochi, Russia.

Journal of Medical Primatology
|May 26, 2018
PubMed

Insights

This study details viral infections in Old World monkeys, including measles, poliomyelitis, and hepatitis A (HPA). Research on simian hemorrhagic fever (SHF) and its virus offers insights into treating human hemorrhagic fevers.

Area of Science:

  • Veterinary Virology
  • Primatology
  • Infectious Diseases

Background:

  • Old World monkeys are susceptible to various viral infections, including measles, poliomyelitis, hepatitis A (HPA), encephalomyocarditis, coronavirus, and simian hemorrhagic fever (SHF).
  • Understanding these spontaneous infections is crucial for primate health and comparative pathology.

Purpose of the Study:

  • To characterize spontaneous viral infections in Old World monkeys.
  • To reproduce experimental infections for studying pathogenesis and epidemiology.
  • To evaluate vaccine efficacy and explore therapeutic strategies for hemorrhagic fevers.

Main Methods:

  • Observation and characterization of spontaneous infections.
  • Reproduction of infections using isolated pathogens in experimental models.
  • Pathogenesis and epidemiological studies on established models.
  • Vaccine efficacy assessment for poliomyelitis, measles, and HPA.
  • Investigation of pathogenic mechanisms using the experimental SHF model.

Main Results:

  • Data on spontaneous infections including measles, poliomyelitis, hepatitis A (HPA), encephalomyocarditis, coronavirus, and simian hemorrhagic fever (SHF) are presented.
  • Experimental models allowed for the study of disease pathogenesis and epidemiology.
  • Vaccine efficacy was demonstrated for poliomyelitis, measles, and HPA.
  • The discovery of SHF and the "Sukhumi" virus was highlighted.
  • Key pathogenic mechanisms of hemorrhagic fevers were elucidated using the experimental SHF model.

Conclusions:

  • Experimental models of viral infections in Old World monkeys are valuable for studying pathogenesis, epidemiology, and vaccine efficacy.
  • The experimental SHF model provides a safe and effective platform for assessing therapies for human hemorrhagic fevers.
  • This research contributes to understanding primate viral diseases and developing treatments for dangerous hemorrhagic fevers.
Keywords:
encephalomyocarditishepatitis Ameaslespoliomyelitissimian hemorrhagic fever

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