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Published on: November 30, 2022
Micelle-Enabled Suzuki-Miyaura Cross-Coupling of Heteroaryl Boronate Esters
Pengfei Guo1, Hao Zhang1, Jianguang Zhou1
1Chemical & Analytical Development , Suzhou Novartis Pharma Technology Company Limited , Changshu , Jiangsu 215537 , China.
Abstract:
We report a micellar protocol for Suzuki-Miyaura cross-coupling of heteroaryl boronic esters with aryl or heteroaryl halides. The micellar catalysis enables this coupling reaction to run under mild conditions, which avoids the decomposition of heteroaryl boronate esters and allows for high chemoselectivity for cross-coupling reaction with 6-chloropridine-2-boronic ester. The micellar protocol expands the scope of the cross-coupling reaction with challenging heteroaryl boronic esters and complements the existing cross-coupling methods for construction of heterobiaryl building blocks.
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