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Updated: Feb 10, 2026
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A Decellularization Methodology for the Production of a Natural Acellular Intestinal Matrix
Published on: October 7, 2013
29.8K
Outcomes of Acellular Dermal Matrix for Immediate Tissue Expander Reconstruction with Radiotherapy: A Retrospective
Elizabeth S Craig1, Mark W Clemens1, John C Koshy1
1Department of Plastic and Reconstructive Surgery, The University of Texas MD Anderson Cancer Center, Houston, TX.
Aesthetic Surgery Journal
|May 26, 2018
Summary
Acellular dermal matrix (ADM) use in breast reconstruction increases infection and seroma rates, but may reduce explantation in patients receiving post-mastectomy radiation therapy (PMRT). Caution is advised for ADM, especially with PMRT.
Area of Science:
- Plastic Surgery
- Oncologic Reconstruction
- Biomaterials in Medicine
Background:
- Acellular dermal matrix (ADM) is increasingly used in expander-based breast reconstruction.
- Its impact on outcomes, particularly with post-mastectomy radiation therapy (PMRT), requires further elucidation.
Purpose of the Study:
- To evaluate the clinical outcomes of immediate tissue expander (ITE) reconstruction with and without ADM, specifically in patients undergoing PMRT.
Main Methods:
- Retrospective review of 957 patients undergoing ITE reconstruction between 2004-2014.
- Patients were stratified into four groups: ADM, ADM with PMRT, non-ADM, and non-ADM with PMRT.
- Complications and outcomes were compared across these cohorts.
Main Results:
- Overall complication rates were higher with ADM (39.0%) compared to non-ADM (16.7%).
- ADM was associated with increased infections and seromas in both radiated and non-radiated groups.
- However, in patients receiving PMRT, ADM use correlated with a significantly lower explantation rate.
Conclusions:
- ADM use in expander-based breast reconstruction warrants caution due to higher complication rates (infections, seromas).
- ADM may offer a benefit in patients undergoing PMRT by reducing implant failure incidence.
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