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Neurodevelopmental outcomes in children with prenatally diagnosed corpus callosal abnormalities

Hye-Ryun Yeh1, Hyo-Kyoung Park2, Hyun-Jin Kim1

  • 1Department of Pediatrics, Asan Medical Center Children's Hospital, University of Ulsan College of Medicine, Seoul, Republic of Korea.

Brain & Development
|May 27, 2018
PubMed

Insights

Children with corpus callosal abnormalities can have varied neurodevelopmental outcomes. Isolated cases often show normal development, but additional anomalies increase the risk of developmental delay.

Area of Science:

  • Neuroscience
  • Developmental Biology
  • Pediatrics

Background:

  • Corpus callosal abnormalities are common prenatal brain malformations.
  • Limited data exists on the long-term neurodevelopmental outcomes for affected children.

Purpose of the Study:

  • To evaluate neurodevelopmental outcomes in children diagnosed with corpus callosal abnormalities prenatally.
  • To identify clinical features associated with these outcomes.

Main Methods:

  • Retrospective study of 49 children with prenatal diagnosis of corpus callosal abnormalities.
  • Neurodevelopmental assessment using standardized tests in 40 patients.
  • Categorization based on postnatal MRI and associated anomalies.

Main Results:

  • 32.7% had isolated agenesis/hypoplasia; 57.1% had other CNS abnormalities.
  • 45% showed normal development, 25% had moderate-to-severe global delay.
  • Isolated cases had favorable outcomes; non-CNS anomalies correlated with delay (OR 2.5).

Conclusions:

  • Corpus callosal abnormalities require thorough evaluation.
  • Combined anomalies necessitate comprehensive therapeutic strategies.
  • Early identification and intervention are crucial for optimizing outcomes.
Abstract

Keywords:
Corpus callosal abnormalityIsolated agenesis of corpus callosumNeurodevelopmental outcomePrenatal diagnosisUltrasonography

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