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Ciliary signalling in cancer.

Hanqing Liu1, Anna A Kiseleva2,3, Erica A Golemis4

  • 1School of Pharmacy, Jiangsu University, Jiangsu, China.

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|May 27, 2018
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Summary
This summary is machine-generated.

Tumor progression and treatment effectiveness rely on the tumor microenvironment (TME). Cilia, crucial for cell signaling and mechanosensation, are altered by cancer and therapies, impacting TME communication and tumor outcomes.

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Area of Science:

  • Oncology
  • Cell Biology
  • Cancer Research

Background:

  • Tumor progression and therapeutic response are influenced by interactions within the tumor microenvironment (TME).
  • The primary monocilium (cilium) is a key signaling hub for pathways like Hedgehog, Notch, WNT, and receptor tyrosine kinases, and is involved in mechanosensation.
  • Alterations in ciliation within cancer cells and the TME impact intercellular signaling during tumor development.

Purpose of the Study:

  • To explore the role of ciliary signaling in the TME.
  • To investigate how cancer cell genomics and anticancer therapies affect ciliation.
  • To understand the implications of ciliary signaling changes for tumor growth and treatment response.

Main Methods:

  • Review of existing literature on ciliation in cancer and the TME.
  • Analysis of signaling pathways (Hedgehog, Notch, WNT, RTKs) and their relationship with cilia.
  • Examination of how oncogenic changes and targeted therapies influence ciliary dynamics.

Main Results:

  • Ciliation changes in cancer cells and TME components contribute to asymmetric intercellular signaling.
  • Certain oncogenic pathways and anticancer drugs can either induce or repress ciliation.
  • The interplay between cancer cell genomics, drug treatment, and ciliary signaling is linked to tumor progression and therapeutic outcomes.

Conclusions:

  • Ciliary signaling is a critical, yet underappreciated, component of the TME.
  • Targeting ciliary function presents a potential therapeutic strategy for cancer.
  • Further research is needed to fully elucidate the complex relationship between ciliation, cancer, and treatment response.