Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Microorganisms in Medicine and Therapeutics01:29

Microorganisms in Medicine and Therapeutics

1.2K
Microorganisms play a fundamental role in vaccine development, gene therapy, and therapeutic production. Their biological properties are harnessed to advance medicine and public health. Beyond immunization, microorganisms contribute to gut health, antibiotic synthesis, and genetic disease treatment.Live Attenuated and Inactivated VaccinesLive attenuated vaccines, such as the measles, mumps, and rubella (MMR) vaccine, utilize weakened forms of pathogens to closely resemble natural infections.
1.2K
Hypertension III: Clinical Manifestations and Diagnostic Studies01:30

Hypertension III: Clinical Manifestations and Diagnostic Studies

614
Hypertension is asymptomatic and also referred to as the "silent killer" until it progresses to a severe stage or causes target organ disease. Patients may experience symptoms stemming from the strain on blood vessels and tissues in various organs or the heart's increased workload.Physical exams might show no abnormalities other than high blood pressure. Signs of vascular damage, when present, correspond to the organs supplied by the affected vessels, leading to target organ damage. For...
614
Rheumatic Heart Disease II: Clinical Manifestations and Diagnostic Studies01:22

Rheumatic Heart Disease II: Clinical Manifestations and Diagnostic Studies

695
The key clinical manifestations of Rheumatic heart disease (RHD) include several distinct cardiac symptoms.Carditis, a hallmark of acute rheumatic fever, involves inflammation of the heart's endocardium, myocardium, and pericardium. Chronic RHD often results from recurrent episodes of carditis. Its symptoms include the following:Murmurs are caused by valvular damage, especially to the mitral and aortic valves. Mitral stenosis or regurgitation is common, with characteristic heart murmurs...
695
Venous Thrombosis II: Clinical Manifestations and Diagnostic Studies01:20

Venous Thrombosis II: Clinical Manifestations and Diagnostic Studies

354
The key difference between Superficial Vein Thrombosis (SVT) and Deep Vein Thrombosis (DVT) lies in their location and severity.Clinical ManifestationsSVT typically presents with localized pain, tenderness, and redness along the course of a superficial vein, often accompanied by a palpable, cord-like structure under the skin. This condition is usually less dangerous than DVT but can be uncomfortable and may lead to complications such as cellulitis or, rarely, a clot extension into the deep...
354
Aneurysm II: Clinical Manifestations and Diagnostic Studies01:21

Aneurysm II: Clinical Manifestations and Diagnostic Studies

386
Thoracic, aortic arch and abdominal aneurysms are significant vascular conditions that can present with various clinical manifestations and lead to serious complications. Understanding these manifestations and the appropriate diagnostic studies is essential for effective management and treatment.Thoracic Aortic AneurysmsThoracic aortic aneurysms often remain asymptomatic until they reach a size that impinges on adjacent structures. They typically cause deep, diffuse chest pain that radiates to...
386
Combination Therapies and Personalized Medicine02:50

Combination Therapies and Personalized Medicine

6.2K
Combining two or more treatment methods increases the life span of cancer patients while reducing damage to vital organs or tissue from the overuse of a single treatment. Combination therapy also targets different cancer-inducing pathways, thus reducing the chances of developing resistance to treatment.
The combination of the drug acetazolamide and sulforaphane is a good example of combination therapy to treat cancer. The cells in the interior of a large tumor often die due to the hypoxic and...
6.2K

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Neutrophil Function in Hematological Neoplasia.

Leukemia & lymphoma·2016
Same author

Combined clozapine-lithium treatment for schizophrenia and schizoaffective disorder.

European psychiatry : the journal of the Association of European Psychiatrists·2009
Same author

Acute myocardial infarction after bone marrow transplantation: an unsuspected late complication.

Annals of hematology·2003
Same author

Molecular diagnosis of FMF: lessons from a study of 446 unrelated individuals.

Clinical and experimental rheumatology·2002
Same author

Effect of ozone on neutrophil function in vitro.

Clinical and laboratory haematology·2001
Same author

A novel computational method for predicting the transmembrane structure of G-protein coupled receptors: application to human C5aR and C3aR.

Receptors & channels·2000

Related Experiment Video

Updated: Feb 16, 2026

Isolation and Characterization of Neutrophil-derived Microparticles for Functional Studies
06:56

Isolation and Characterization of Neutrophil-derived Microparticles for Functional Studies

Published on: March 2, 2018

10.8K

Neutrophil function studies in clinical medicine.

Y Matzner1

  • 1Hematology Unit, Hadassah University Hospital, Jerusalem, Israel.

Transfusion Medicine Reviews
|December 1, 1987
PubMed
Summary

Simple tests can screen for neutrophil disorders, aiding early infection risk assessment. Comprehensive neutrophil function analysis is vital for definitive diagnosis and treatment planning.

Area of Science:

  • Immunology
  • Hematology

Background:

  • Comprehensive neutrophil function evaluation is costly and requires specialized labs.
  • Preliminary screening for infection predisposition can utilize simpler, cost-effective methods.

Purpose of the Study:

  • To outline accessible methods for preliminary neutrophil function screening.
  • To highlight the diagnostic utility of neutrophil function tests in primary and secondary disorders.

Main Methods:

  • Review of established diagnostic techniques for neutrophil function.
  • Description of simple screening tests: blood film examination, Rebuck skin window test, NBT test, and peroxidase staining.
  • Mention of specialized tests for definitive diagnosis and genetic counseling.

Main Results:

More Related Videos

Methods to Study Lipid Alterations in Neutrophils and the Subsequent Formation of Neutrophil Extracellular Traps
10:58

Methods to Study Lipid Alterations in Neutrophils and the Subsequent Formation of Neutrophil Extracellular Traps

Published on: March 29, 2017

10.0K
Isolation, Purification and Labeling of Mouse Bone Marrow Neutrophils for Functional Studies and Adoptive Transfer Experiments
07:28

Isolation, Purification and Labeling of Mouse Bone Marrow Neutrophils for Functional Studies and Adoptive Transfer Experiments

Published on: July 10, 2013

64.0K

Related Experiment Videos

Last Updated: Feb 16, 2026

Isolation and Characterization of Neutrophil-derived Microparticles for Functional Studies
06:56

Isolation and Characterization of Neutrophil-derived Microparticles for Functional Studies

Published on: March 2, 2018

10.8K
Methods to Study Lipid Alterations in Neutrophils and the Subsequent Formation of Neutrophil Extracellular Traps
10:58

Methods to Study Lipid Alterations in Neutrophils and the Subsequent Formation of Neutrophil Extracellular Traps

Published on: March 29, 2017

10.0K
Isolation, Purification and Labeling of Mouse Bone Marrow Neutrophils for Functional Studies and Adoptive Transfer Experiments
07:28

Isolation, Purification and Labeling of Mouse Bone Marrow Neutrophils for Functional Studies and Adoptive Transfer Experiments

Published on: July 10, 2013

64.0K
  • Blood film examination aids in diagnosing Chediak-Higashi syndrome and specific granule deficiency.
  • Rebuck skin window test assesses chemotactic defects.
  • NBT test screens for chronic granulomatous disease.
  • Peroxidase staining helps detect myeloperoxidase deficiency.
  • Neutrophil function assays can identify secondary defects in inflammatory conditions like familial Mediterranean fever, psoriasis, Behcet's, and Sweet's syndromes.

Conclusions:

  • Simple, inexpensive tests provide valuable preliminary screening for neutrophil disorders.
  • Neutrophil function studies are crucial for diagnosing primary immunodeficiencies and secondary defects in inflammatory diseases.
  • These assays aid in diagnosis, monitoring disease activity, and evaluating treatment response.