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Related Experiment Videos

Using time-to-pregnancy data to study occupational exposures: methodology.

D D Baird1

  • 1Epidemiology Branch, National Institute of Environmental Health Sciences, Research Triangle Park, North Carolina 27709.

Reproductive Toxicology (Elmsford, N.Y.)
|January 1, 1988
PubMed
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This study introduces a new measure of fecundability (monthly pregnancy probability) to assess occupational and environmental impacts on fertility. Preliminary findings suggest reduced fertility may not increase spontaneous abortion risk.

Area of Science:

  • Reproductive Epidemiology
  • Occupational Health
  • Environmental Medicine

Background:

  • Occupational and environmental factors influencing fertility remain largely unstudied due to a lack of sensitive measurement methods.
  • Assessing reproductive impairment requires reliable metrics for fecundability and its relationship with adverse pregnancy outcomes.

Purpose of the Study:

  • To develop and validate a measure of fecundability, defined as the monthly probability of pregnancy, using time to pregnancy (TTP).
  • To investigate the correlation between reduced fertility and the risk of spontaneous abortion.
  • To address data quality and selection bias in fertility studies, particularly concerning occupational exposures.

Main Methods:

  • Utilizing time to pregnancy (TTP) as a measure of fecundability, representing noncontracepting menstrual cycles required for conception.

Related Experiment Videos

  • Comparing data quality from mail questionnaires and telephone interviews against detailed telephone interview data in a study of dental assistants' occupational exposures.
  • Estimating selection biases, including the exclusion of accidental pregnancies and underrepresentation of highly infertile or sterile couples.

    • Main Results:

    • Preliminary data from two sources indicate that reduced fertility is not strongly correlated with an increased risk of spontaneous abortion.
    • This finding contrasts with predictions from existing toxicology literature.

    Conclusions:

    • The developed measure of fecundability offers a sensitive approach to studying occupational and environmental influences on fertility.
    • Further research is needed to fully understand the complex interplay between fertility impairment, pregnancy outcomes, and exposure assessment methodologies.