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Residual Renal Function and Obstructive Sleep Apnea in Peritoneal Dialysis: A Pilot Study
Aviya Lanis1, Eric Kerns1,2,3, Susie L Hu1,2,3
1Alpert Medical School of Brown University, 222 Richmond Street, Providence, RI, USA.
Lung
|May 28, 2018
Summary
Obstructive sleep apnea is common in patients on peritoneal dialysis. Lower residual kidney function, not dialysis specifics, is linked to more severe sleep apnea in these patients.
Area of Science:
- Nephrology
- Pulmonology
- Sleep Medicine
Background:
- Obstructive sleep apnea (OSA) is prevalent in end-stage renal disease (ESRD) patients.
- ESRD-specific factors may influence OSA pathophysiology.
- The impact of peritoneal dialysis (PD) on OSA is not well understood.
Purpose of the Study:
- Investigate OSA prevalence in peritoneal dialysis patients.
- Assess the relationship between PD-specific measures and OSA.
- Determine the role of residual kidney function in OSA among PD patients.
Main Methods:
- Recruited ESRD patients on nocturnal automated PD for ≥3 months.
- Collected data on dialysis adequacy, peritoneal membrane transport, and residual renal function.
- Utilized home sleep apnea testing (Level III monitor) for OSA diagnosis.
Main Results:
- 33% of participants had OSA (apnea-hypopnea index ≥5).
- Renal creatinine clearance negatively correlated with apnea-hypopnea index (ρ = -0.63, p = 0.012).
- No significant associations found between OSA and anthropometric measures, intra-abdominal dwell volume, or peritoneal transporter status.
Conclusions:
- High prevalence of OSA and sleep disturbances in PD patients.
- Elevated apnea-hypopnea index is associated with reduced residual renal function.
- Dialysis-specific measures (e.g., dwell volume, transporter status) do not correlate with OSA severity.
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