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Updated: Feb 10, 2026

Estimating Bilateral Atrial Function by Cardiovascular Magnetic Resonance Feature Tracking in Patients with Paroxysmal Atrial Fibrillation
Published on: July 20, 2022
Subclinical atrial fibrillation frequency and associated parameters in patients with cardiac resynchronization
Mehmet Uğurlu1, Onur Kaypakli2, Durmuş Yıldıray Şahin1
1Department of Cardiology, University of Health Sciences - Adana Health Practices and Research Center, Adana, Turkey.
Insights
Subclinical atrial fibrillation (SCAF) is common in cardiac resynchronization therapy (CRT) patients. Left atrial diameter, CHA2DS2-VASc score, and atrial threshold independently predict SCAF risk.
Area of Science:
- Cardiology
- Electrophysiology
- Medical Devices
Background:
- Subclinical atrial fibrillation (SCAF) poses risks like stroke in cardiac resynchronization therapy (CRT) patients.
- Identifying SCAF is crucial for managing anticoagulation therapy in CRT recipients.
Purpose of the Study:
- To determine the frequency of SCAF in patients undergoing CRT.
- To identify clinical and device-related parameters associated with SCAF development.
Main Methods:
- 191 CRT patients (mean age 65.9 years) were monitored for atrial high-rate episodes.
- SCAF was defined as asymptomatic episodes lasting 6 minutes to 24 hours.
- Device parameters including atrial lead thresholds and P-wave amplitude were analyzed.
Main Results:
- SCAF was detected in 23.2% of CRT patients.
- Left atrial diameter, CHA2DS2-VASc score, and atrial threshold were independent predictors of SCAF.
- Increased LA diameter and CHA2DS2-VASc score significantly elevated SCAF risk.
Conclusions:
- CRT patients exhibit a higher prevalence of SCAF compared to the general population.
- CHA2DS2-VASc score, LA diameter, and atrial threshold are valuable, accessible markers for identifying SCAF risk.
Aim:
The presence of subclinical atrial fibrillation (SCAF) is relevant to issues such as the risk of stroke and the necessity of anticoagulant use in patients with cardiac resynchronization therapy (CRT). Our study aimed to investigate SCAF frequency and associated parameters in patients with CRT.
Methods:
One hundred ninety-one patients with CRT (77 females, 114 males, mean age 65.9 ± 9.8) were included in the study. Atrial high-rate episodes detected by the device, atrial electrode impedance, P-wave sense amplitude, and atrial lead threshold values were measured during pacemaker controls. SCAF was defined as asymptomatic atrial high-rate episodes (AHRE) longer than 6 min and shorter than 24 h. Patients were divided into two groups as with and without SCAF.
Results:
SCAF was detected in 44 (23.2%) of 191 patients with CRT. Age, sex, weight, aortic end-systolic diameter, left atrium (LA) diameter, left bundle branch block morphology, CHA2DS2-VASc score, and right atrium thresholds were associated with SCAF. In multivariate regression analysis, CHA2DS2-VASc score, LA diameter, and atrial threshold values were found to be independent predictors of SCAF occurrence. According to this analysis, every 1 point increase in CHA2DS2-VASc score, every 1 mm increase in LA diameter, and every 0.1 V increase in atrial threshold increased the risk of SCAF by 32.5, 59.6, and 14.6%, respectively. In the ROC analysis, the area under the curve (AUC) was 0.870, 0.638, and 0,652 for LA diameter, CHA2DS2-VASc score, and atrial lead threshold, respectively (p < 0.05, for all). The cut-off values were 34 mm, 3, and 0.6 V for LA diameter, CHA2DS2-VASc score, and atrial lead threshold, respectively.
Conclusion:
Patients with CRT have significantly higher frequency of SCAF than the normal population. CHA2DS2-VASc score, LA diameter, and atrial threshold values were considered to be useful and easily applicable parameters in identifying the patients to develop SCAF.
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