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Right-Sided Infective Endocarditis: A 6-Year Retrospective Cohort Study from a Tertiary Care Center in Türkiye
Bedia Mutay Suntur1, Gülhan Yüksel2, İbrahim Halil Kurt2
1Department of Infectious Diseases and Clinical Microbiology, University of Health Sciences, Adana City Training and Research Hospital, Adana, Türkiye.
Anatolian Journal of Cardiology
|July 3, 2026
Summary
Right-sided infective endocarditis (RSIE) is increasingly common, often linked to intravenous drug use (IVDU). While IVDU patients have better survival, hemodialysis and age are key mortality predictors in RSIE.
Area of Science:
- Cardiology
- Infectious Diseases
- Public Health
Background:
- Right-sided infective endocarditis (RSIE) frequency is rising due to evolving risk factors.
- Limited data exists on RSIE, with no dedicated cohort from Türkiye.
- This study addresses the need for RSIE epidemiological and clinical characteristic data.
Purpose of the Study:
- To describe RSIE epidemiological and clinical features in a Turkish tertiary-care center.
- To identify factors associated with mortality in RSIE patients.
- To compare outcomes between intravenous drug use (IVDU) and non-IVDU groups.
Main Methods:
- Retrospective cohort study of 65 adult RSIE patients (Jan 2018-Jan 2024).
- Analysis of demographics, risk factors, echocardiography, pathogens, and outcomes.
- Statistical comparison between IVDU and non-IVDU cohorts.
Main Results:
- The cohort was predominantly male (76.9%), median age 36. IVDU was the main risk factor (55.4%).
- Staphylococcus aureus was the leading pathogen (79%). Septic pulmonary embolism occurred in 81.6%.
- Overall mortality was 26.2%. IVDU patients had lower mortality (17.4% vs 44%, P=.036). Hemodialysis (OR=6.72), hemoglobin, and age predicted mortality.
Conclusions:
- RSIE in Türkiye is strongly linked to IVDU and often presents with respiratory symptoms from septic pulmonary emboli.
- IVDU patients showed higher survival, potentially due to younger age and fewer comorbidities.
- RSIE is critical, requiring high clinical suspicion and prompt intervention.
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