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Zinc deficiency and its predictive capacity for anemia: Unique model in school children

Halil Ibrahim Atasoy1, Guler Bugdayci2

  • 1Departments of Pediatrics, Abant Izzet Baysal University, Faculty of Medicine, Golkoy, Bolu, Turkey.

Pediatrics International : Official Journal of the Japan Pediatric Society
|May 28, 2018
PubMed

Insights

Low zinc levels were strongly associated with anemia in school children. This suggests that zinc deficiency significantly contributes to anemia in this age group, highlighting the importance of monitoring zinc status.

Area of Science:

  • Pediatric Nutrition
  • Hematology
  • Nutritional Biochemistry

Background:

  • Zinc deficiency is prevalent in children, but its link to anemia requires further clarification.
  • Understanding the relationship between zinc status and anemia is crucial for public health interventions.

Purpose of the Study:

  • To identify zinc deficiency in school-aged children.
  • To investigate the association between zinc status and hemoglobin levels.
  • To explore the predictive capacity of zinc for anemia.

Main Methods:

  • A case-control study involving 349 children aged 6.5–14.8 years from primary schools in Bolu, Turkey.
  • Measurements included anthropometrics, complete blood count, serum zinc, ferritin, vitamin B12, and folate.
  • Hierarchical multiple regression and receiver operating characteristic (ROC) analyses were employed.

Main Results:

  • 10.9% of children exhibited low serum zinc, and 6.0% were anemic.
  • Anemia prevalence was significantly higher in the zinc-deficient group (31.5%) compared to the zinc-sufficient group (2.9%).
  • Serum zinc showed the strongest association with hemoglobin levels; a serum zinc cut-off of 71.5 μg/dL predicted anemia.

Conclusions:

  • Low zinc status is a significant contributing factor to anemia in school-aged children.
  • The strong association between zinc and hemoglobin underscores the importance of zinc for red blood cell formation.
  • Monitoring and addressing zinc deficiency may be an effective strategy for anemia prevention in children.
Abstract

Keywords:
anemiaferritinfolatevitamin B12zinc deficiency

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