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[Comorbidities and concomitant medication use in adult patients with chronic hepatitis C: a descriptive

Q Wang1, H Y Rao1, N Yu2

  • 1Peking University People's Hospital, Peking University Hepatology Institute, Beijing Key Laboratory of Hepatitis C and Immunotherapy for Liver Diseases, Beijing 100044, China.

Zhonghua Gan Zang Bing Za Zhi = Zhonghua Ganzangbing Zazhi = Chinese Journal of Hepatology
|May 28, 2018
PubMed

Insights

Adults with chronic hepatitis C frequently have diabetes, hypertension, and heart disease. Managing these chronic hepatitis C comorbidities requires careful attention to potential drug-drug interactions from concomitant medications.

Area of Science:

  • Hepatology
  • Epidemiology
  • Pharmacology

Background:

  • Chronic hepatitis C (HCV) is a significant global health concern.
  • Understanding comorbidities and medication use in HCV patients is crucial for effective management.

Purpose of the Study:

  • To investigate the prevalence of comorbidities in adult patients with chronic hepatitis C.
  • To analyze the concomitant medication patterns for these comorbidities.

Main Methods:

  • A descriptive epidemiological study.
  • Utilized data from the China Medical Insurance database (2013-2015).
  • Analyzed a cohort of 2,958 adult patients with chronic HCV.

Main Results:

  • Top comorbidities included diabetes, hypertension, ischemic heart disease, gastroduodenitis, and HBV/HCV co-infection.
  • Common medications for diabetes: acarbose, metformin, repaglinide.
  • Medications for hypertension: nifedipine, amlodipine, metoprolol.
  • Medications for ischemic heart disease: aspirin, nifedipine, amlodipine.
  • Medications for gastroduodenitis: omeprazole, pantoprazole, levofloxacin.
  • Medications for HBV/HCV co-infection: ribavirin, peginterferon alfa-2a/2b.

Conclusions:

  • Diabetes, hypertension, ischemic heart disease, gastroduodenitis, and HBV/HCV co-infection are the most common comorbidities in chronic hepatitis C patients.
  • Concomitant medication use in these patients presents a risk of potential drug-drug interactions.

Keywords:
ComorbidityConcomitant medicationsDrug-drug interactionsHepatitis C, chronic

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