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Updated: Feb 10, 2026

Surgical Models of Gastroesophageal Reflux with Mice
Published on: August 25, 2015
[Overweight and gastro-oesophageal reflux disease]
Melina Capello1, Anne Lund Karup, Peter Rask
1nielsenm@post7.tele.dk.
Abstract:
The increase in the prevalence of obesity is paralleled by an increase in gastro-oesophageal reflux disease (GERD), and several mechanisms link GERD and obesity, so weight loss is a cornerstone in the treatment of GERD. Sustained weight loss often requires surgery, and fundoplication is the first surgical choice among normal weight patients with reflux; however, reflux complications increase with increasing BMI. Therefore, patients with obesity and GERD should be treated with gastric bypass surgery. The aim of this article is to discuss the relationship between overweight and GERD and outline treatment options of this disease.
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