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Single-Molecule Tracking Microscopy - A Tool for Determining the Diffusive States of Cytosolic Molecules
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Small molecule tools in mitosis research.

Franziska Teusel1, Lars Henschke1, Thomas U Mayer1

  • 1Konstanz Research School Chemical Biology (KoRS-CB), University of Konstanz, Konstanz, Germany.

Methods in Cell Biology
|May 29, 2018
PubMed
Summary

Small molecules are essential tools for studying mitosis, a complex cellular process. This chapter reviews compounds that affect mitosis and provides protocols for their use in cell culture research.

Keywords:
Chemical biologyCytoskeletonMitosisMitotic kinasesMitotic phosphatasesMitotic spindleMotor proteinsSmall molecule inhibitorsSmall molecules

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Area of Science:

  • Cell Biology
  • Molecular Biology

Background:

  • Mitosis is a fundamental cellular process crucial for cell division and organism development.
  • The dynamic and complex nature of mitosis presents challenges for dissecting the functions of mitotic proteins.
  • Small molecules offer a powerful approach to investigate mitotic mechanisms due to their rapid and reversible actions.

Purpose of the Study:

  • To provide a comprehensive overview of small molecules that impact mitosis.
  • To discuss the diverse applications of small molecules in studying mitotic processes.
  • To offer practical guidance and protocols for utilizing small molecules in mitosis research.

Main Methods:

  • Literature review of existing small molecule compounds affecting mitosis.
  • Discussion of application fields and considerations for using small molecules.
  • Development of detailed protocols for experimental use in tissue culture cells.

Main Results:

  • Identification and categorization of various small molecules targeting different aspects of mitosis.
  • Elucidation of key considerations for the effective and accurate application of these compounds.
  • Provision of two validated protocols for studying mitosis using small molecules in cell-based assays.

Conclusions:

  • Small molecules are indispensable tools for functional dissection of mitosis.
  • Effective utilization of small molecules requires careful consideration of their properties and applications.
  • The provided protocols facilitate the experimental study of mitosis in cellular models.