Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Protein-protein Interfaces02:04

Protein-protein Interfaces

14.8K
Many proteins form complexes to carry out their functions, making protein-protein interactions (PPIs) essential for an organism's survival. Most PPIs are stabilized by numerous weak noncovalent chemical forces. The physical shape of the interfaces determines the way two proteins interact. Many globular proteins have closely-matching shapes on their surfaces, which form a large number of weak bonds. Additionally, many PPIs occur between two helices or between a surface cleft and a...
14.8K
Protein-Protein Interfaces02:04

Protein-Protein Interfaces

4.5K
4.5K
Group Design02:01

Group Design

10.7K
The most basic experimental design involves two groups: the experimental group and the control group. The two groups are designed to be the same except for one difference— experimental manipulation. The experimental group gets the experimental manipulation—that is, the treatment or variable being tested—and the control group does not. Since experimental manipulation is the only difference between the experimental and control groups, we can be sure that any differences between...
10.7K
Neural Regulation01:37

Neural Regulation

43.5K
Digestion begins with a cephalic phase that prepares the digestive system to receive food. When our brain processes visual or olfactory information about food, it triggers impulses in the cranial nerves innervating the salivary glands and stomach to prepare for food.
43.5K
Factorial Design02:01

Factorial Design

14.1K
Factorial Analysis is an experimental design that applies Analysis of Variance (ANOVA) statistical procedures to examine a change in a dependent variable due to more than one independent variable, also known as factors. Changes in worker productivity can be reasoned, for example, to be influenced by salary and other conditions, such as skill level. One way to test this hypothesis is by categorizing salary into three levels (low, moderate, and high) and skills sets into two levels (entry level...
14.1K
Genetic Material01:20

Genetic Material

3.8K
Within the human body, a complex and detailed system of trillions of cells works in unison to sustain life. Each cell houses a nucleus, which contains 46 chromosomes divided into 23 pairs. Chromosomes are highly coiled structures made of the genetic material DNA. These chromosomes are essential carriers of genetic information, with half inherited from the mother through her egg and the other half from the father's sperm, combining to create the unique genetic makeup of an individual.
3.8K

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Substance P regulates Tacr1 neurons, which control nitric oxide-mediated neurovascular coupling in the mouse cortex.

Science advances·2026
Same author

Microelectrode arrays enable directional stereo-EEG during kainate-mediated seizures.

bioRxiv : the preprint server for biology·2026
Same author

Chronic alteration of Ca<sup>2+</sup> and hemodynamic signals induced by intracortical microstimulation in the visual cortex of awake mice.

Biomaterials·2026
Same author

Identification of low threshold off-target activation pathways during stimulation of carotid baroreceptor afferents in swine.

Journal of neural engineering·2026
Same author

Solving the problem of inception: a cross-species perspective on strategies for a mechanistic refinement of intracortical microstimulation.

Journal of neural engineering·2026
Same author

Prevalence of sympathetic fibers within the rat cervical vagus, and functional consequence on physiological effects mediated by vagus nerve stimulation (VNS).

Journal of neural engineering·2026
Same journal

Shear-Induced CROSS (Cellular RedOx Spreading Shield) Assembly Sustains Neurotrophic Extracellular Vesicle Production for Functional Neural Networks.

Advanced functional materials·2026
Same journal

Buckling-Resistant and Trace-Stacked (BRATS) Design Enables Aid-Free Implantation of Flexible Multielectrode Array with Minimized Inflammatory Tissue Response.

Advanced functional materials·2026
Same journal

Rationally designed anisotropic and auxetic hydrogel patches for adaptation to dynamic organs.

Advanced functional materials·2026
Same journal

Benchtop Fabrication and Integration of Laser-Induced Graphene Strain Gauges and Stimulation Electrodes in Muscle on a Chip Devices.

Advanced functional materials·2026
Same journal

Controlling 3D Contractility via Engineered Fibrous Hydrogel Composites.

Advanced functional materials·2026
Same journal

Cardiac-Derived ECM Microspheres for Enhanced hiPSC-CMs Maturation.

Advanced functional materials·2026
See all related articles

Related Experiment Video

Updated: Feb 10, 2026

Using Synthetic Biology to Engineer Living Cells That Interface with Programmable Materials
10:28

Using Synthetic Biology to Engineer Living Cells That Interface with Programmable Materials

Published on: March 9, 2017

9.6K

A Materials Roadmap to Functional Neural Interface Design.

Steven M Wellman1, James R Eles1, Kip A Ludwig2

  • 1Department of Bioengineering, Center for the Basis of Neural Cognition, McGowan Institute of Regenerative Medicine, NeuroTech Center, University of Pittsburgh Brain Institute, Center for Neuroscience at the University of Pittsburgh, University of Pittsburgh, 208 Center for Biotechnology, 300 Technology Dr., Pittsburgh, PA 15219, United States.

Advanced Functional Materials
|May 29, 2018
PubMed
Summary
This summary is machine-generated.

Advancements in neural interfaces face challenges from biological responses and material degradation. This review highlights how interdependent electrode components impact long-term performance and biocompatibility for neural engineering.

Keywords:
BioelectronicsElectrodesMicroelectromechanical SystemsPhotonicsSensors/Biosensors

More Related Videos

Voltage Biasing, Cyclic Voltammetry, & Electrical Impedance Spectroscopy for Neural Interfaces
07:51

Voltage Biasing, Cyclic Voltammetry, & Electrical Impedance Spectroscopy for Neural Interfaces

Published on: February 24, 2012

25.2K
Characterization of the Sense of Agency over the Actions of Neural-machine Interface-operated Prostheses
05:21

Characterization of the Sense of Agency over the Actions of Neural-machine Interface-operated Prostheses

Published on: January 7, 2019

8.4K

Related Experiment Videos

Last Updated: Feb 10, 2026

Using Synthetic Biology to Engineer Living Cells That Interface with Programmable Materials
10:28

Using Synthetic Biology to Engineer Living Cells That Interface with Programmable Materials

Published on: March 9, 2017

9.6K
Voltage Biasing, Cyclic Voltammetry, & Electrical Impedance Spectroscopy for Neural Interfaces
07:51

Voltage Biasing, Cyclic Voltammetry, & Electrical Impedance Spectroscopy for Neural Interfaces

Published on: February 24, 2012

25.2K
Characterization of the Sense of Agency over the Actions of Neural-machine Interface-operated Prostheses
05:21

Characterization of the Sense of Agency over the Actions of Neural-machine Interface-operated Prostheses

Published on: January 7, 2019

8.4K

Area of Science:

  • Neuroscience and Biomedical Engineering
  • Materials Science for Neural Interfaces

Background:

  • Neurotechnologies for electrophysiology, sensing, and modulation are advancing brain research and neurological disorder treatments.
  • Chronic neural interfaces face challenges like biological inflammation, neural degeneration, and material instability, degrading interface quality over time.

Purpose of the Study:

  • To review the material-based challenges in neural interface engineering.
  • To highlight the interdependence of electrode components and their impact on performance and biocompatibility.

Main Methods:

  • Review of recent advances in functional materials for neural interfaces.
  • Analysis of multi-dimensional interactions between physical properties of neural probes.
  • Discussion of challenges hindering regulatory approval for novel neural interface materials.

Main Results:

  • Novel materials introduce new, unaddressed challenges in neural interface development.
  • Focusing on individual probe parameters overlooks critical multi-dimensional interactions.
  • Interdependence of electrode components significantly affects long-term performance and biocompatibility.

Conclusions:

  • Material-based challenges, particularly the interdependence of electrode components, are critical for chronic neural interface engineering.
  • Addressing these material science challenges is essential for achieving regulatory approval and clinical translation of neural interfaces.