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Updated: Feb 10, 2026

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Cronkhite-Canada syndrome: A case report.

Wei Yuan1,2, Li Tian1, Fei-Yan Ai1

  • 1Department of Gastroenterology, Hunan Key Laboratory of Non-Resolving Inflammation and Cancer, The Third Xiangya Hospital of Central South University, Changsha, Hunan 410013, P.R. China.

Oncology Letters
|May 29, 2018
PubMed
Summary

Cronkhite-Canada syndrome (CCS) is a rare gastrointestinal disorder. This case study details a 58-year-old male diagnosed with CCS, highlighting its key symptoms and diagnostic methods.

Keywords:
Cronkhite-Canada syndromehyperpigmentationonychodystrophypolyposis

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Area of Science:

  • Gastroenterology
  • Rare Diseases
  • Autoimmune Disorders

Background:

  • Cronkhite-Canada syndrome (CCS) is a rare, non-inherited condition.
  • Characterized by gastrointestinal hamartomatous polyposis, alopecia, onychodystrophy, hyperpigmentation, weight loss, and diarrhea.
  • The etiology is suspected to be autoimmune.

Purpose of the Study:

  • To report a case of Cronkhite-Canada syndrome (CCS).
  • To illustrate the clinical presentation, diagnostic process, and confirmation of CCS.

Main Methods:

  • Patient history collection including symptoms like diarrhea, hematochezia, abdominal pain, and nail loss.
  • Physical examination.
  • Endoscopic evaluation for gastrointestinal polyposis.
  • Histological analysis of polyps.

Main Results:

  • A 58-year-old male presented with a 4-month history of diarrhea and hematochezia, 1 month of abdominal pain, and half a month of nail and toenail loss.
  • Clinical, endoscopic, and histological findings confirmed the diagnosis of CCS.
  • Over 500 cases of CCS have been reported globally, emphasizing its rarity.

Conclusions:

  • Cronkhite-Canada syndrome diagnosis relies on a combination of clinical presentation, endoscopic findings, and histology.
  • This case underscores the importance of recognizing the diverse symptoms of CCS for timely diagnosis and management.
  • Further research into the autoimmune etiology of CCS may lead to improved therapeutic strategies.