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IDOL gene variant is associated with hyperlipidemia in Han population in Xinjiang, China

Dilare Adi1,2, Jialin Abuzhalihan1,2, Ying-Hong Wang3

  • 1State Key Laboratory of Pathogenesis, Prevention and Treatment of High Incidence Diseases in Central Asia, Department of Cardiology, The First Affiliated Hospital of Xinjiang Medical University, Urumqi, 830054, People's Republic of China.

Scientific Reports
|September 2, 2020
PubMed

Insights

Genetic variants in the human IDOL gene are linked to hyperlipidemia, a risk factor for atherosclerosis. Specifically, the rs9370867 SNP in the IDOL gene is an independent risk factor for hyperlipidemia in the Han population.

Area of Science:

  • Genetics
  • Cardiovascular Disease Epidemiology

Background:

  • Hyperlipidemia is a primary risk factor for atherosclerosis and coronary artery disease (CAD).
  • Understanding the genetic underpinnings of hyperlipidemia is crucial for developing targeted prevention and treatment strategies.

Purpose of the Study:

  • To investigate the association between specific genetic variants of the human IDOL gene and hyperlipidemia in the Han population of Xinjiang, China.
  • To identify potential genetic markers for hyperlipidemia risk.

Main Methods:

  • A case-control study involving 1,172 Han Chinese subjects (588 hyperlipidemia cases, 584 controls).
  • Genotyping of three IDOL gene SNPs (rs9370867, rs909562, rs2072783) using the improved multiplex ligation detection reaction (iMLDR) method.
  • Statistical analysis including genotype distribution, dominant, recessive, and overdominant models, with multivariate adjustments for confounders.

Main Results:

  • Significant differences in genotype distribution, dominant, and overdominant models were observed for the rs9370867 SNP between cases and controls (P < 0.001).
  • Significant differences in genotype distribution and recessive models were found for rs909562 (P = 0.002, P = 0.007) and rs2072783 (P = 0.045, P = 0.02).
  • The rs9370867 SNP remained an independent risk factor for hyperlipidemia after multivariate adjustment (OR = 1.380, 95% CI = 1.201-1.586, P < 0.001).

Conclusions:

  • The rs9370867 variant of the human IDOL gene is significantly associated with hyperlipidemia in the Han population.
  • IDOL gene variants may play a role in the development of hyperlipidemia and associated cardiovascular diseases.

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