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Updated: Feb 10, 2026

Synthesis of a Water-soluble Metal–Organic Complex Array
Published on: October 8, 2016
A Glutathione-Responsive Short Sequence of Metal-Organic Complex Array
Purnandhu Bose1, Toshiaki Takei2, Xianglan Li2
1International Center for Materials Nanoarchitectonics (WPI-MANA), National Institute for Materials Science, 1-1 Namiki, Tsukuba, Ibaraki, 305-0044, Japan.
Abstract:
A short metal-organic complex array (MOCA) containing a sequence of RPtRRu (1Cl ) was found to exhibit unique responses to a major biothiol, glutathione (GSH). Upon binding of GSH to 1Cl , the resultant 1:1 complex (1GS ) formed nanofibrous assemblies that suggested supramolecular polymerization through the double-salt-bridge structure formation. The binding behavior of this MOCA sequence to calf thymus DNA was also dependent on GSH; a larger conformational change of DNA was observed upon binding with 1GS , relative to that with 1Cl .
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