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Updated: Feb 10, 2026

In Vitro Thrombosis Test for Ventricular Assist Devices
Published on: March 21, 2025
An Alternative Approach by HeartWare Ventricular Assist Device in Hypertrophic Cardiomyopathy
Katsuhide Maeda1, Teimour Nasirov1, David N Rosenthal2
1Department of Cardiothoracic Surgery, Stanford University Medical Center, Stanford, California.
Insights
A novel transatrial left atrial cannulation technique offers a safe alternative for ventricular assist device implantation in hypertrophic cardiomyopathy patients, avoiding apex cannulation complications.
Area of Science:
- Cardiology
- Medical Devices
- Surgical Techniques
Background:
- Hypertrophic cardiomyopathy (HCM) presents challenges for left ventricular assist device (LVAD) support due to small ventricular cavities and drainage issues.
- Traditional LVAD apex cannulation is often difficult in HCM patients.
Observation:
- A HeartWare ventricular assist device was implanted using a novel transatrial approach.
- The device was connected to the left atrium via the right atrium, utilizing an interposition graft across the atrial septum.
Findings:
- The patient was successfully discharged after 111 days of LVAD support.
- No complications, including thromboembolic events, were observed during the support period.
- The patient subsequently underwent a successful heart transplant.
Implications:
- This transatrial left atrial cannulation technique represents a viable alternative for LVAD implantation in HCM.
- The technique demonstrates safety and efficacy when used with the HeartWare LVAD system.
- It may improve outcomes for HCM patients requiring mechanical circulatory support.
Abstract:
Hypertrophic cardiomyopathy is known to be difficult to support by left ventricular assist device because of the small ventricular cavity and inadequate drainage. Therefore, instead of cannulating on the left ventricular apex, a HeartWare ventricular assist device (HeartWare, Framingham, MA) was connected to the left atrium through right atrium onto atrial septum using ringed Gore-Tex (W.L. Gore & Associates, Flagstaff, AZ) interposition graft. The patient has been discharged home after ventricular assist device implant and underwent successful heart transplant after 111 days of support without any complications including any thromboembolic events. This new transatrial left atrial cannulation technique can be an alternative approach for ventricular assist device cannulation in hypertrophic cardiomyopathy. It can be safely performed with the HeartWare ventricular assist device.
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