Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Overview of Advanced Functional Groups02:22

Overview of Advanced Functional Groups

30.1K

Functional groups are groups of atoms with specific chemical properties that occur within organic molecules and are sometimes denoted as “R”. Functional groups can “functionalize” a compound by enabling it to adopt different physical and chemical properties.
Types of Advanced Functional Groups
The table below summarizes some of the major functional groups in organic chemistry.
30.1K
Extraction: Advanced Methods00:56

Extraction: Advanced Methods

1.2K
Metal ions can be separated from one another by complexation with organic ligands–the chelating agent– to form uncharged chelates. Here, the chelating agent must contain hydrophobic groups and behave as a weak acid, losing a proton to bind with the metal. Since most organic ligands used in this process are insoluble or undergo oxidation in the aqueous phase, the chelating agent is initially added to the organic phase and extracted into the aqueous phase. The metal-ligand complex is...
1.2K
Cholinergic Antagonists: Pharmacological Actions01:28

Cholinergic Antagonists: Pharmacological Actions

1.8K
Antimuscarinic drugs block muscarinic receptors in multiple systems, including the gut, eye, smooth muscles, respiratory tract, cardiovascular, and central nervous systems. They produce similar effects with varying selectivity depending on the specific agent and tissue. Here are the key pharmacological actions of antimuscarinics:
Gastrointestinal Effects: Antimuscarinics reduce gut contractions, increase gastric emptying, and slow intestinal transit. They partly inhibit gastric acid secretion...
1.8K
Regulation of Stroke Volume01:27

Regulation of Stroke Volume

5.2K
The regulation of stroke volume, which is the amount of blood the heart pumps out during each heartbeat, is critical for maintaining a healthy circulatory system. Stroke volume is influenced by three main factors: preload, contractility, and afterload.
Preload refers to the degree of stretch on the heart before it contracts. It's analogous to the stretching of a rubber band; the more it's stretched, the more forcefully it snaps back. This concept is encapsulated in the Frank-Starling law of the...
5.2K
Drug Abuse and Addiction: Pharmacological Phenomena01:15

Drug Abuse and Addiction: Pharmacological Phenomena

1.3K
Drug dependence, abuse, and addiction are complex phenomena that can precipitate various abnormal states. Physical dependence refers to a state of pharmacological adaptation to a drug. This adaptation often results in tolerance—a reduced response to the drug after repeated administrations. When the drug use is abruptly stopped, withdrawal symptoms occur due to the body's need to readjust from the pharmacologically induced imbalance. However, tolerance and withdrawal symptoms do not...
1.3K
Cardiopulmonary Resuscitation IV: Pharmacological Management01:25

Cardiopulmonary Resuscitation IV: Pharmacological Management

851
Pharmacologic intervention is crucial in treating cardiac arrest patients during ACLS or Advanced Cardiovascular Life Support. The ACLS algorithms guide the administration of specific drugs based on the patient's cardiac arrest rhythm, which includes pulseless ventricular tachycardia (VT), ventricular fibrillation (VF), asystole, and pulseless electrical activity (PEA).EpinephrineIndication: Epinephrine is the first-line drug for all cardiac arrest rhythms.Mechanism of Action: Epinephrine...
851

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Review on isotachophoresis in trace biochemical sample analysis: state of art and future prospects.

Journal of chromatography. A·2026
Same author

An immunoinformatics-derived multi-epitope DNA vaccine targeting the Micropterus salmoides rhabdovirus G protein elicits protective immunity in largemouth bass.

Fish & shellfish immunology·2026
Same author

Peptide-Propofol Prodrug with Self-Assembly and Triggered Release for Antidepressant Therapy.

ACS applied materials & interfaces·2026
Same author

Microbiota-driven gut-brain signaling underlies antidepressant effects of a GLP-1 analog.

Cell host & microbe·2026
Same author

Revolutionizing MDD diagnosis: the integrated role of circRNAs and biosensor technology.

Molecular psychiatry·2026
Same author

Circular RNA SCMH1 promotes persistent brain repair via N6-methyladenosine methylation post stroke.

Brain : a journal of neurology·2026

Related Experiment Video

Updated: Feb 10, 2026

The Mouse Stroke Unit Protocol with Standardized Neurological Scoring for Translational Mouse Stroke Studies
10:45

The Mouse Stroke Unit Protocol with Standardized Neurological Scoring for Translational Mouse Stroke Studies

Published on: February 7, 2025

1.6K

Advances in stroke pharmacology.

Zhenhua Zhou1, Jianfei Lu2, Wen-Wu Liu3

  • 1Department of Physiology and Pharmacology, Loma Linda University School of Medicine, Loma Linda, CA, USA; Department of Neurology, Southwest Hospital, the Third Military Medical University, Chongqing 400038, China.

Pharmacology & Therapeutics
|May 29, 2018
PubMed
Summary

This review covers new pharmacological treatments for stroke, focusing on neuroprotection and neurorestoration. It highlights recent advances and clinical trials to improve stroke therapy outcomes.

Keywords:
Animal studiesClinical trialsNeuroprotectionPharmacologyStroke

More Related Videos

Modeling Stroke in Mice: Focal Cortical Lesions by Photothrombosis
06:07

Modeling Stroke in Mice: Focal Cortical Lesions by Photothrombosis

Published on: May 6, 2021

7.7K
Embolic Middle Cerebral Artery Occlusion MCAO for Ischemic Stroke with Homologous Blood Clots in Rats
09:11

Embolic Middle Cerebral Artery Occlusion MCAO for Ischemic Stroke with Homologous Blood Clots in Rats

Published on: September 17, 2014

27.8K

Related Experiment Videos

Last Updated: Feb 10, 2026

The Mouse Stroke Unit Protocol with Standardized Neurological Scoring for Translational Mouse Stroke Studies
10:45

The Mouse Stroke Unit Protocol with Standardized Neurological Scoring for Translational Mouse Stroke Studies

Published on: February 7, 2025

1.6K
Modeling Stroke in Mice: Focal Cortical Lesions by Photothrombosis
06:07

Modeling Stroke in Mice: Focal Cortical Lesions by Photothrombosis

Published on: May 6, 2021

7.7K
Embolic Middle Cerebral Artery Occlusion MCAO for Ischemic Stroke with Homologous Blood Clots in Rats
09:11

Embolic Middle Cerebral Artery Occlusion MCAO for Ischemic Stroke with Homologous Blood Clots in Rats

Published on: September 17, 2014

27.8K

Area of Science:

  • Neuroscience
  • Pharmacology
  • Neurology

Background:

  • Stroke is a leading cause of death and disability globally, resulting from blocked or ruptured cerebral blood vessels.
  • Current pharmacological treatments for stroke are limited, with few agents like rtPA succeeding in clinical trials.
  • Understanding stroke's pathophysiology has revived research into neuroprotective and neurorestorational agents.

Purpose of the Study:

  • To review recent progress in pharmacological stroke treatment, particularly for ischemic stroke.
  • To summarize emerging therapeutic mechanisms and novel molecular targets for neuroprotection and neurorestoration.
  • To highlight recent clinical trials and bridge basic research with clinical management.

Main Methods:

  • Literature review of pharmacological studies in stroke.
  • Analysis of emerging therapeutic mechanisms and molecular targets.
  • Summary of recent clinical trial outcomes.

Main Results:

  • Few pharmacological agents have proven effective in clinical trials besides rtPA.
  • Novel molecular targets for neuroprotection and neurorestoration are being discovered.
  • Recent research shows promise in developing new therapeutic strategies for stroke.

Conclusions:

  • Pharmacological interventions for stroke are an active area of research with emerging potential.
  • Advances in understanding stroke pathophysiology are guiding the development of new treatments.
  • This review aims to guide clinical management by connecting basic and translational research.