Related Experiment Video
Updated: Feb 10, 2026
12:04
The bm12 Inducible Model of Systemic Lupus Erythematosus SLE in C57BL/6 Mice
Published on: November 1, 2015
18.7K
[Systemic Lupus Erythematosus (SLE) - New Classification Criteria].
Martin Aringer1, Thomas Dörner2
1Medizinische Klinik und Poliklinik III, Universitätsklinikum und Medizinische Fakultät Carl Gustav Carus an der TU Dresden.
Deutsche Medizinische Wochenschrift (1946)
|May 29, 2018
Summary
New systemic lupus erythematosus (SLE) classification criteria confirm ANA positivity and establish remission standards. Advances include improved therapeutics like belimumab and anifrolumab, with mycophenolate outperforming azathioprine.
Area of Science:
- Rheumatology
- Immunology
- Internal Medicine
Background:
- Systemic lupus erythematosus (SLE) classification requires updated criteria.
- Established remission criteria are needed for consistent patient management.
- Therapeutic advancements are crucial for managing SLE.
Purpose of the Study:
- To present new EULAR/ACR classification criteria for SLE.
- To define international consensus remission criteria for SLE.
- To review recent therapeutic insights and advancements in SLE treatment.
Main Methods:
- Development and validation of new SLE classification criteria.
- Establishment of international consensus on SLE remission criteria.
- Review of clinical trials and therapeutic data for SLE.
Main Results:
- New SLE classification criteria incorporate ANA as an entry criterion.
- Remission criteria defined by absence of inflammation and low-dose glucocorticoids.
- Hydroxychloroquine shows low risk of visual impairment; mycophenolate superior to azathioprine.
- Belimumab weekly SC formulation approved; anifrolumab shows therapeutic promise.
Conclusions:
- Updated SLE classification and remission criteria provide a standardized framework.
- Therapeutic options for SLE are expanding, offering improved patient outcomes.
- Ongoing research continues to refine SLE management strategies.
Related Concept Videos
01:26Classification of Systems-I
601
Linearity is a system property characterized by a direct input-output relationship, combining homogeneity and additivity.
Homogeneity dictates that if an input x(t) is multiplied by a constant c, the output y(t) is multiplied by the same constant. Mathematically, this is expressed as:
Homogeneity dictates that if an input x(t) is multiplied by a constant c, the output y(t) is multiplied by the same constant. Mathematically, this is expressed as:
601
01:31Classification of Systems-II
514
Continuous-time systems have continuous input and output signals, with time measured continuously. These systems are generally defined by differential or algebraic equations. For instance, in an RC circuit, the relationship between input and output voltage is expressed through a differential equation derived from Ohm's law and the capacitor relation,
514
01:28Criteria for Causality: Bradford Hill Criteria - II
1.3K
The Bradford Hill criteria serve as guidelines for establishing causative links in epidemiological research. Beyond Strength, Consistency, Specificity, and Temporality, key criteria also include Biological Gradient, Plausibility, Coherence, Experiment, and Analogy. These principles assist scientists in assessing the likelihood of causation in complex biological contexts. Below is a summary of these concepts:
1.3K
01:30Criteria for Causality: Bradford Hill Criteria - I
1.2K
The Bradford Hill criteria are a group of principles that provide a framework to determine a causal relationship between a specific factor and a disease. There are nine criteria that are pivotal in assessing causality in epidemiological studies. Here's a closer look at Strength, Consistency, Specificity, and Temporality criteria with definitions and examples:
1.2K
01:22Force Classification
2.4K
Forces play a crucial role in the study of physics and engineering. They are essential in describing the motion, behavior, and equilibrium of objects in the physical world. Forces can be classified based on their origin, type, and direction of action.
Contact and non-contact forces are two of the most widely used categories of forces. As the name suggests, contact forces require physical contact between two objects to act upon each other. Examples of contact forces include frictional,...
Contact and non-contact forces are two of the most widely used categories of forces. As the name suggests, contact forces require physical contact between two objects to act upon each other. Examples of contact forces include frictional,...
2.4K
01:30Classification of Neurotransmitters
5.3K
Neurotransmitters play a crucial role in the communication between neurons in the autonomic nervous system. Neurons in the autonomic nervous system can be cholinergic or adrenergic depending on the neurotransmitters synthesized. Cholinergic neurons use acetylcholine as their primary neurotransmitter. This includes all the preganglionic fibers of the sympathetic and pre- and postganglionic fibers of the parasympathetic nervous systems. In addition, neurons of the somatic nervous system also use...
5.3K