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An apparent phosphate selenium interaction in weaner sheep.

J F Hudman1, N D Costa, W F Robinson

  • 1School of Business and Technology, MacArthur Institute of Higher Education, Campbelltown, New South Wales, Australia.

Journal of Trace Elements and Electrolytes in Health and Disease
|June 1, 1988
PubMed
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High phosphate levels worsen selenium deficiency myopathy in sheep by lowering liver selenium. This interaction may occur within the animal or the gastrointestinal tract, impacting selenium status.

Area of Science:

  • Animal Science
  • Nutritional Biochemistry
  • Veterinary Medicine

Background:

  • Selenium is crucial for preventing nutritional myopathy in sheep.
  • Phosphate's role in selenium metabolism and deficiency disorders is not fully understood.
  • Nutritional myopathy is a significant health concern in weaner sheep.

Purpose of the Study:

  • To investigate the effect of soluble phosphate on selenium-dependent nutritional myopathy in sheep.
  • To determine if phosphate influences selenium tissue concentrations, particularly in the liver.
  • To explore potential interactions between selenium and phosphate in sheep's gastrointestinal tract and systemic circulation.

Main Methods:

  • Weaner sheep were infused ruminally with soluble phosphate or sodium chloride.

Related Experiment Videos

  • Selenium concentrations in various tissues (liver, kidney, heart, muscle, blood) were measured.
  • Blood glutathione peroxidase (GSH.Px) activity was assessed.
  • Radioactive 75[Se]selenate was used to trace selenium absorption and interaction in the gastrointestinal tract.

    • Main Results:

    • Ruminal phosphate infusion significantly increased the severity of selenium-dependent nutritional myopathy.
    • Liver selenium concentrations were significantly lower in sheep receiving phosphate compared to controls.
    • Blood GSH.Px activity was elevated in affected sheep, contrary to typical selenium deficiency indicators.
    • Tissue selenium levels, except in the liver, showed no significant differences between groups.
    • Evidence suggested a selenium-phosphate interaction in both the gastrointestinal tract and the animal's system.

    Conclusions:

    • Soluble phosphate exacerbates selenium deficiency myopathy in sheep, likely by reducing liver selenium levels.
    • A significant interaction between selenium and phosphate occurs, affecting selenium bioavailability and potentially leading to myopathy.
    • This interaction may manifest within the gastrointestinal tract and/or systemically, impacting overall selenium status in sheep.