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Plasma metabolite profiles in children with current asthma
R S Kelly1, J E Sordillo2, J Lasky-Su1
1Channing Division of Network Medicine, Brigham and Women's Hospital, Boston, MA, USA.
Summary
Asthma in children may be linked to specific metabolites, including those from the nicotinamide pathway and gut bacteria. Further research could reveal new diagnostic or therapeutic targets for childhood asthma.
Area of Science:
- Metabolomics
- Pediatric Asthma Research
- Biomarker Discovery
Background:
- Understanding asthma pathophysiology in children is crucial.
- Metabolomic profiling offers a potential avenue for deeper insights.
Purpose of the Study:
- To identify differences in plasma metabolites between children with and without current asthma.
- To explore the metabolome's potential in distinguishing asthma cases from controls in mid-childhood.
Main Methods:
- Untargeted mass spectrometry was used to analyze plasma metabolites in a pediatric cohort (Project Viva).
- Partial least squares discriminant analysis assessed the overall metabolic profile's discriminatory ability.
- Logistic regression identified individual metabolites associated with asthma status, with replication in the VDAART trial.
Main Results:
- No systematic metabolomic difference was observed between children with and without asthma.
- Several metabolites, including N1-Methyl-2-pyridone-5-carboxamide and p-cresol sulphate, showed nominal associations with current asthma.
- Replication of associations for N1-Methyl-2-pyridone-5-carboxamide and p-cresol sulphate in an independent cohort confirmed their potential relevance.
Conclusions:
- Current asthma in children is nominally associated with altered levels of specific metabolites.
- These include metabolites from the nicotinamide pathway and gut microbiome.
- Findings suggest potential biomarkers for childhood asthma, warranting further investigation.
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