Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Overview of Cell-Matrix Interactions01:24

Overview of Cell-Matrix Interactions

9.1K
The extracellular matrix or ECM holds cells together to form a tissue and allows the cells within the tissue to communicate. ECM comprises proteins such as fibronectin, collagen, laminin, etc. The most abundant protein in this space is collagen. Collagen fibers are interwoven with carbohydrate-containing protein molecules called proteoglycans. ECM allows cell migration and provides a structural scaffold at cell adhesion that anchors the cell when the extracellular matrix proteins interact with...
9.1K
Peptide Bonds02:43

Peptide Bonds

83.4K
A peptide bond covalently attaches amino acids through a dehydration reaction. One amino acid's carboxyl group and another amino acid's amino group combine, releasing a water molecule. The resulting bond is the peptide bond. The products that such linkages form are peptides. As more amino acids join this growing chain, the resulting chain is a polypeptide. Each polypeptide has a free amino group at one end. This end has the N-terminal, or the amino-terminal, and the other end has a free...
83.4K
Mechanism of Breathing I: Inspiration01:30

Mechanism of Breathing I: Inspiration

3.3K
Introduction to Inspiration: The Respiratory System in Action
The respiratory system, an essential network for breathing, comprises the conducting and respiratory zones, each playing a crucial role in the overall process of respiration. Let us explore the detailed mechanism of inspiration, or inhalation, which is the first phase of the respiratory cycle.
Pathway of Air during Inspiration
During inspiration, air enters our body through the nose or mouth and moves through the conducting zone,...
3.3K
Drawing Free-body Diagrams: Rules01:16

Drawing Free-body Diagrams: Rules

15.9K
The first step in describing and analyzing most phenomena in physics involves the careful drawing of a free-body diagram. Free-body diagrams are useful in analyzing forces acting on an object or system, and are employed extensively in the study and application of Newton's laws of motion. The steps to draw a free-body diagram are listed below:
15.9K
The Extracellular Matrix01:42

The Extracellular Matrix

89.3K
Overview
89.3K
The Extracellular Matrix01:29

The Extracellular Matrix

12.3K
Overview
In order to maintain tissue organization, many animal cells are surrounded by structural molecules that make up the extracellular matrix (ECM). Together, the molecules in the ECM maintain the structural integrity of tissue as well as the remarkable specific properties of certain tissues.
Composition of the Extracellular Matrix
The extracellular matrix (ECM) is commonly composed of ground substance, a gel-like fluid, fibrous components, and many structurally and functionally diverse...
12.3K

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Controlled release of bone morphogenetic protein-2 improves motor function after traumatic brain injury in a rat model.

Journal of materials chemistry. B·2026
Same author

Interface Performance Enhancement in 3D-Printed Biphasic Scaffolds with Interlocking Hourglass Geometry.

Annals of biomedical engineering·2025
Same author

Comparison of the chondrogenic potential of eBMSCs and eUCMSCs in response to selected peptides and compounds.

BMC veterinary research·2025
Same author

Improved Mesenchymal Stem Cell Viability in High-Stiffness, Translational Cartilage Matrix Hydrogels.

Tissue engineering. Part A·2025
Same author

Osteochondral Regeneration With Anatomical Scaffold 3D-Printing-Design Considerations for Interface Integration.

Journal of biomedical materials research. Part A·2024
Same author

Regenerative Engineering of a Biphasic Patient-Fitted Temporomandibular Joint Condylar Prosthesis.

Tissue engineering. Part C, Methods·2023

Related Experiment Video

Updated: Feb 10, 2026

Biotinylated Cell-penetrating Peptides to Study Intracellular Protein-protein Interactions
10:26

Biotinylated Cell-penetrating Peptides to Study Intracellular Protein-protein Interactions

Published on: December 20, 2017

9.9K

Chondroinductive Peptides: Drawing Inspirations from Cell-Matrix Interactions.

Salma Mahzoon1, Michael S Detamore2

  • 11 School of Aerospace and Mechanical Engineering, University of Oklahoma, Norman, Oklahoma.

Tissue Engineering. Part B, Reviews
|May 30, 2018
PubMed
Summary
This summary is machine-generated.

Synthetic peptides offer a promising biomaterial strategy for cartilage regeneration. These peptides mimic natural signals, potentially guiding cell fate and enabling true hyaline cartilage formation without costly growth factors.

Keywords:
bioactive peptidecartilage regenerationchondroinductivesynthetic biomaterial

More Related Videos

Author Spotlight: Optimization of Ultrashort Peptide Matrices for Colorectal Cancer Organoids
10:23

Author Spotlight: Optimization of Ultrashort Peptide Matrices for Colorectal Cancer Organoids

Published on: May 3, 2024

1.5K
Identifying Protein-protein Interaction Sites Using Peptide Arrays
07:44

Identifying Protein-protein Interaction Sites Using Peptide Arrays

Published on: November 18, 2014

18.6K

Related Experiment Videos

Last Updated: Feb 10, 2026

Biotinylated Cell-penetrating Peptides to Study Intracellular Protein-protein Interactions
10:26

Biotinylated Cell-penetrating Peptides to Study Intracellular Protein-protein Interactions

Published on: December 20, 2017

9.9K
Author Spotlight: Optimization of Ultrashort Peptide Matrices for Colorectal Cancer Organoids
10:23

Author Spotlight: Optimization of Ultrashort Peptide Matrices for Colorectal Cancer Organoids

Published on: May 3, 2024

1.5K
Identifying Protein-protein Interaction Sites Using Peptide Arrays
07:44

Identifying Protein-protein Interaction Sites Using Peptide Arrays

Published on: November 18, 2014

18.6K

Area of Science:

  • Regenerative Medicine
  • Biomaterials Science
  • Tissue Engineering

Background:

  • Developing biomaterial devices that independently influence cellular fate is a key goal in regenerative medicine.
  • Native tissues and growth factors are ideal signaling sources but present translational challenges like cost and reproducibility.
  • Synthetic peptides are emerging as alternatives to mimic crucial biological signals for tissue regeneration.

Purpose of the Study:

  • To review the significance of peptide signaling in cartilage regeneration.
  • To highlight the potential of synthetic peptides in overcoming limitations associated with traditional regenerative approaches.
  • To explore the development of peptide-based biomaterials for inducing chondrogenesis.

Main Methods:

  • Review of current literature on peptide signaling in regenerative medicine.
  • Analysis of cell-adhesion signaling pathways in cartilage.
  • Discussion of synthetic peptide design for mimicking native tissue cues.

Main Results:

  • Cell-adhesion signaling is critical for cartilage cell functions like migration, growth, and differentiation.
  • Synthetic peptides can be designed to replicate these essential cell-adhesion sequences.
  • Peptide-based biomaterials hold potential for directing cellular fate in cartilage tissue engineering.

Conclusions:

  • Synthetic peptides represent a viable strategy to control cellular fate in biomaterial devices.
  • Peptide-based materials could enable the regeneration of hyaline cartilage, avoiding fibrous tissue formation.
  • This approach may revolutionize arthritis treatment by providing a cost-effective and reproducible regenerative solution.