Predictors of neuropsychological outcome after pediatric concussion

Miriam H Beauchamp1, Mary Aglipay2, Keith Owen Yeates3

  • 1Department of Psychology, University of Montreal.

Neuropsychology
|May 30, 2018
PubMed

Insights

Pediatric concussion outcomes are influenced by both pre-existing factors and injury-related variables, not just unmodifiable traits. Acute cognitive screening is key for predicting long-term neuropsychological status after concussion.

Area of Science:

  • Pediatric neurology
  • Neuropsychology
  • Traumatic brain injury research

Background:

  • Pediatric concussion outcomes were previously thought to be determined by unmodifiable, pre-existing factors.
  • This study challenges that notion by exploring a wider range of predictors.

Purpose of the Study:

  • To predict neuropsychological outcome after pediatric concussion using a large sample size.
  • To investigate the contribution of premorbid factors, acute symptoms, and acute cognitive screening to outcomes.

Main Methods:

  • 311 children and adolescents (6-18 years) with concussion were assessed.
  • Cognitive functioning and acute symptoms were documented in the emergency department.
  • Neuropsychological tests were administered at 4 and 12 weeks post-injury; regression analyses were performed.

Main Results:

  • Neuropsychological impairment was observed in 10.3% at 4 weeks and 4.5% at 12 weeks.
  • At 4 weeks, cognitive inefficiency was linked to premorbid factors and acute screening; at 12 weeks, acute symptoms were predictive.
  • Neuropsychological performance at 4 weeks was influenced by premorbid factors, acute symptoms, and screening; at 12 weeks, only acute screening was predictive.

Conclusions:

  • Pediatric concussion outcomes are associated with a combination of pre-existing and injury-related variables.
  • Acute cognitive screening is a valuable tool for predicting neuropsychological status post-concussion.
Abstract

Related Concept Videos

Predicting Reaction Outcomes02:24

Predicting Reaction Outcomes

Kinetics describes the rate and path by which a reaction occurs. In contrast, thermodynamics deals with state functions and describes the properties, behavior, and components of a system. It is not concerned with the path taken by the process and cannot address the rate at which a reaction occurs. Although it does provide information about what can happen during a reaction process, it does not describe the detailed steps of what appears on an atomic or a molecular level. On the other hand,...
11.0K
Outcomes of Glycolysis01:13

Outcomes of Glycolysis

Nearly all the energy used by cells comes from the bonds that make up complex organic compounds. These organic compounds are broken down into simpler molecules, such as glucose. As a result, cells extract energy from glucose over many chemical reactions—a process called cellular respiration.
Cellular respiration can occur aerobically (with oxygen) or anaerobically (without oxygen). In the presence of oxygen, cellular respiration starts with glycolysis and continues with pyruvate...
107.6K
Guidelines for Writing Outcome01:11

Guidelines for Writing Outcome

When developing expected outcomes for a patient care plan, the nurse should adhere to the following recommendations:
Patient outcomes reflect the patient's response to the goal rather than what the nurse aims to achieve. Terminology should be observable and measurable to avoid the reader's interpretation. The desired outcome should be realistic and achievable in the designated care timeframe. Expected outcomes should align with adjunctive therapies. The outcome should enhance care...
4.0K
Pharmacokinetics in Pediatric Patients: Drug Excretion01:26

Pharmacokinetics in Pediatric Patients: Drug Excretion

In pediatric medicine, understanding the renal function and drug elimination nuances is crucial for administering safe and effective treatments. Newborns, in particular, display markedly slower renal functions than adults, profoundly affecting how drugs are cleared from their bodies. This slower drug clearance requires clinicians to extend the dosing intervals for many medications to prevent drug accumulation and toxicity while ensuring therapeutic efficacy.One key area where these adjustments...
274
Pharmacokinetics in Pediatric Patients: Drug Distribution01:17

Pharmacokinetics in Pediatric Patients: Drug Distribution

Drug distribution in the pediatric population exhibits unique challenges and considerations due to the physiological differences between children, particularly neonates and infants, and adults. A crucial aspect of pediatric pharmacology is understanding how these differences impact the pharmacokinetics of various drugs, necessitating age-specific dosing strategies to ensure efficacy and safety.Neonates and infants have a higher total body water content, ~75%–90% of their body weight,...
326
Pharmacokinetics in Pediatric Patients: Drug Metabolism01:24

Pharmacokinetics in Pediatric Patients: Drug Metabolism

In pediatric care, understanding the nuances of hepatic drug metabolism is crucial, as it significantly differs from that of adults. This divergence is primarily due to the developmental stage of drug-metabolizing enzymes, which affects how medications are processed in the body. In neonates, for instance, the activity of Phase I enzymes—critical for the initial breakdown of drugs—is markedly reduced, functioning at just 20–40% of the levels seen in adults. This reduction poses...
242