The influence of opiate agonists on day-night feeding rhythms in young and old mice

Daily rhythms of feeding behavior and responses to ketocyclazocine, morphine and naloxone were measured in young (1-2 months) and old (24-30 months) male CF-1 mice. All of the mice consumed more food at night than in the day-time, though this nocturnal peak was markedly reduced in the old animals, who consumed more in the day. The young mice also displayed a significant nocturnal enhancement in ketocyclazocine- and morphine-stimulated feeding. This day-night rhythm in ingestive responses was absent in the old mice. In comparison to the young mice, the opiate-stimulated food consumptions of the old animals were reduced at all times. Additionally, the old animals failed to show any day-night variations in the suppressive effects of naloxone on deprivation-induced food intake that were displayed by the young animals.