Oxidative Stress in Elderly with Different Cognitive Status: My Mind Project
Patrizia Fattoretti1, Marco Malavolta2, Paolo Fabbietti3
1Cellular Bioenergetics Laboratory, Center for Neurobiology of Aging, INRCA-IRCCS, Ancona, Italy.
Journal of Alzheimer'S Disease : JAD
|May 31, 2018
Summary
Oxidative stress biomarkers did not differ between Alzheimer's disease (AD), mild cognitive impairment (MCI), and healthy elderly. Gender, not oxidative status, influenced outcomes, limiting biomarker utility for AD/MCI prognosis.
Area of Science:
- Neuroscience
- Biochemistry
- Gerontology
Background:
- Oxidative stress biomarkers are linked to cognitive function and proposed for Alzheimer's disease (AD) and mild cognitive impairment (MCI) prognosis.
- Investigating these biomarkers in AD, MCI, and healthy elderly (HE) is crucial for understanding cognitive decline.
Purpose of the Study:
- To compare oxidative stress status in plasma of mild-moderate AD, MCI, and HE groups.
- To evaluate the impact of a multi-modal cognitive training intervention on oxidative stress markers.
Main Methods:
- A prospective randomized trial with 321 elderly participants in Italy.
- Biomarkers (BAP/d-ROM ratio) and cognitive performance assessed at baseline and multiple follow-ups.
- Random assignment to cognitive training or control groups.
Main Results:
- No significant differences in oxidative stress status were found among AD, MCI, and HE groups.
- The cognitive intervention did not yield significant changes in oxidative stress markers.
- Gender was the only factor significantly affecting the BAP/d-ROM ratio.
Conclusions:
- The utility of oxidative stress biomarkers for guiding AD/MCI prognosis and treatment appears limited.
- Lack of specificity, high interindividual variability, and gender bias restrict the clinical application of these biomarkers.
- Further research is needed to identify reliable biomarkers for cognitive disorders.
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