Related Experiment Video
Updated: Feb 9, 2026

Orthotopic Mouse Model of Colorectal Cancer
Published on: December 4, 2007
Development of an Experimental Model for Analyzing Drug Resistance in Colorectal Cancer
Mohamed Elbadawy1,2, Tatsuya Usui3, Hideyuki Yamawaki4
1Laboratory of Veterinary Pharmacology, Department of Veterinary Medicine, Faculty of Agriculture, Tokyo University of Agriculture and Technology, 3-5-8 Saiwai-cho, Fuchu, Tokyo 183-8509, Japan. mohamed.elbadawy@fvtm.bu.edu.eg.
Abstract:
Colorectal cancer (CRC) is one of the most common cancers, for which combination treatment of chemotherapy is employed. However, most patients develop drug resistance during the course of treatment. To clarify the mechanisms of drug resistance, various research models have been developed. Recently, we established a human CRC patients-derived three-dimensional (3D) culture system using an air-liquid interface organoid method. It contained numerous cancer stem cells and showed resistance to 5-fluorouracil and Irinotecan. In this review, we introduce conventional and our established models for studying drug resistance in CRC.
Related Concept Videos
Development of Antibiotic Resistance
Treatment Resistant Cancers
Resistivity
Resistance
In Vitro Drug Release Testing: Overview, Development and Validation
Mouse Models of Cancer Study
The development of transgenic, knockout, and knock-in mice has led to an exponential increase in their use as model organisms in research,...

