Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Network meta-analysis: users' guide for pediatricians.

Reem Al Khalifah1,2, Ivan D Florez3,4, Gordon Guyatt3,5

  • 1Department of Clinical Epidemiology & Biostatistics, McMaster University, Hamilton, ON, Canada. ralkhalifah@ksu.edu.sa.

BMC Pediatrics
|May 31, 2018
PubMed
Summary

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

The Psychometric Properties of the Type 1 Diabetes Mellitus Screening Acceptability Assessment (DMSA) Scale among General Population.

Pediatric diabetes·2025
Same author

Early Detection of Type 1 Diabetes in First-Degree Relatives in Saudi Arabia (VISION-T1D): Protocol for a Pilot Implementation Study.

JMIR research protocols·2025
Same author

Vitamin D Supplementation for Children with Epilepsy on Antiseizure Medications: A Randomized Controlled Trial.

Children (Basel, Switzerland)·2024
Same author

The Impact of Light-Dark Cycle Alteration on the Acceleration of Type 1 Diabetes in NOD Mice Model.

Nature and science of sleep·2024
Same author

Recombinant PTH Infusion in a Child With Sanjad-Sakati Syndrome Refractory to Conventional Therapy.

JCEM case reports·2024
Same author

Safety and user experience with off-label use of a flash glucose monitor (FreeStyle Libre<sup>®</sup> 1) among very young children with type 1 diabetes mellitus.

Journal of pediatric endocrinology & metabolism : JPEM·2023
This summary is machine-generated.

Network meta-analysis (NMA) offers a powerful way to compare multiple treatments, even without direct comparisons. This guide helps clinicians evaluate NMA credibility and evidence quality for pediatric applications.

Area of Science:

  • Medical Research Methodology
  • Evidence Synthesis
  • Pediatric Clinical Trials

Background:

  • Network meta-analysis (NMA) enables simultaneous comparison of multiple treatment alternatives.
  • It is particularly useful when direct comparative data between treatments are unavailable.
  • The application of NMA in pediatrics is increasing, necessitating clinician familiarity.

Purpose of the Study:

  • To guide clinicians in evaluating the credibility of network meta-analysis methods.
  • To provide a framework for assessing the quality and certainty of NMA evidence.
  • To illustrate these concepts using examples from pediatric NMA publications.

Main Methods:

  • Evaluation requires assessing standard meta-analysis practices (search, eligibility, bias, data abstraction).
Keywords:
Evidence certaintyEvidence credibilityMultiple treatment comparisonsMultiple-treatment meta-analysis evidence synthesisNetwork meta-analysisPediatric

Related Experiment Videos

  • Specific NMA criteria include evaluating precision, transitivity, coherence, and ranking of treatments.
  • The article discusses how to make judgments on the credibility and quality of NMA.

    • Main Results:

    • Clinicians need to apply both general meta-analysis standards and NMA-specific criteria.
    • Systematic evaluation ensures the reliability of evidence synthesized through NMA.
    • Understanding these methods is crucial for interpreting pediatric NMA findings.

    Conclusions:

    • Network meta-analysis is a valuable tool for synthesizing evidence in pediatrics.
    • Clinicians must critically appraise NMA methodology and evidence quality.
    • This article provides practical guidance for evaluating pediatric NMAs.