Related Experiment Video
Updated: Feb 9, 2026
04:43
Author Spotlight: Insights and Innovations in Gene Expression Manipulation Techniques for Choroid Plexus Research
Published on: June 16, 2023
1.6K
Decreased choroidal thickness in vitiligo patients
Serkan Demirkan1, Zafer Onaran2, Güzin Samav3
1Department of Dermatology and Venerology, Kirikkale University Faculty of Medicine, Yenisehir District, Tahsin Duru Avenue, No:14, Yahsihan, Kirikkale, Turkey. serkan.demirkan@yahoo.com.tr.
BMC Ophthalmology
|May 31, 2018
Summary
Vitiligo patients exhibit thinner choroidal thickness compared to healthy individuals, suggesting melanocyte loss may impact eye structures. This finding highlights potential ocular implications of vitiligo.
Area of Science:
- Ophthalmology
- Dermatology
- Cell Biology
Background:
- Vitiligo is a depigmentation disorder resulting from melanocyte loss, potentially affecting ocular tissues beyond the skin.
- The exact mechanism of melanocyte destruction in vitiligo remains unclear.
- Ocular structures like the choroid may be involved in vitiligo pathogenesis.
Purpose of the Study:
- To investigate and compare choroidal thickness in patients with vitiligo versus a control group.
- To assess the potential impact of vitiligo on ocular structures using advanced imaging techniques.
Main Methods:
- Utilized spectral-domain optical coherence tomography (SD-OCT) for high-resolution retinal imaging.
- Employed statistical analysis with SPSS 21.0 software for data interpretation.
Main Results:
- Vitiligo patients demonstrated significantly thinner choroidal thickness across most measurements compared to the control group.
- The optic nerve area was an exception, showing no significant difference in thickness between groups.
Conclusions:
- The findings suggest that vitiligo, characterized by melanocyte loss, may lead to reduced choroidal thickness.
- Melanocyte depletion in vitiligo could influence the structural integrity of the choroid.
More Related Videos
Related Concept Videos
01:27Decreasing Function
305
A decreasing function describes a relationship where the output consistently declines as the input increases. This means that for any two input values, if one is greater than the other, the corresponding output is smaller. Mathematically, a function f is decreasing on an interval I if for every x1 < x2 in I, f (x1) > f (x2). This type of behavior is visually identified on a graph that slopes downward from left to right.The nature of a function can be analyzed by calculating...
305
01:29Decreased Body Temperature
1.1K
A decreased body temperature can occur in patients with hypothermia and frostbite. Heat loss with extended cold exposure overpowers the body's ability to create heat, resulting in hypothermia. Core temperature readings help classify hypothermia. Mild hypothermia is temperatures between 32 °C (89.6 °F) and 35°C (95 °F) and is caused by impaired thermoregulation. Moderate hypothermia is temperatures between 28 C (82.4 °F) and 32 °C (89.6 °F) caused by...
1.1K
01:14Decreased pulse rate
918
Bradycardia is a medical condition in which the heart rate is slower than normal. It occurs when the heart's natural pacemaker, the sinus node, generates slower electrical impulses than the standard rhythm. In adults, bradycardia is diagnosed when the pulse rate falls below 60 beats per minute, indicating a deviation from the normal heart rate range.
There are specific risk factors that can elevate the likelihood of developing bradycardia. Advanced age is a significant factor, with...
There are specific risk factors that can elevate the likelihood of developing bradycardia. Advanced age is a significant factor, with...
918
01:23Design Example: Deciding Thickness of Lubricating Fluid in a Shaft
346
Effective lubrication between a rotating shaft and its bearing housing is essential in rotating machinery to minimize friction, wear, and energy loss. With carefully controlled thickness and viscosity, the lubricant layer prevents metal-to-metal contact, ensuring smooth operation.
To calculate the required thickness of the lubricant layer, the tangential velocity at the shaft's surface must first be determined. This velocity is calculated by converting the rotational speed to angular velocity...
To calculate the required thickness of the lubricant layer, the tangential velocity at the shaft's surface must first be determined. This velocity is calculated by converting the rotational speed to angular velocity...
346
01:13Patient-centered Care
3.1K
Patient-centered care involves delivering care beyond inpatient hospitalization. Reflective practice can enhance a patient-centered approach. Reflective practice is a process of reasoning that considers all aspects of the present situation, including practicalities, learning from personal practice, and consideration of patient needs. Patients appreciate care decisions made while considering their input. Involving the patient in their care provides the patient with a sense of contribution rather...
3.1K
01:15Drug Dosing: Geriatric Patients
278
Elderly individuals encompass a diverse population with varying degrees of age-related physiological changes. Defining the elderly presents challenges, as the geriatric population is often arbitrarily categorized as individuals older than 65. However, many individuals in this group lead active and healthy lives, with an increasing number surpassing 85 years and falling into the older elderly category. Physiological changes associated with aging impact performance capacity and homeostatic...
278