Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Autophagy01:27

Autophagy

5.9K
Autophagy is a self-digesting process by which a cell protects itself from threats both within and outside the cell, ranging from abnormal proteins to invading bacteria. In this process, obsolete components of the cell and invading microbes are degraded by hydrolytic enzymes active in an acidic environment of the lysosomal lumen.
An autophagic pathway consists of a series of signaling events activated in response to diverse stress and physiological conditions such as food deprivation,...
5.9K
Oxygen Delivering System III: Tracheostomy and T-piece01:23

Oxygen Delivering System III: Tracheostomy and T-piece

6.4K
Oxygen delivery is critical in clinical care, especially for patients with respiratory disorders or those undergoing surgical procedures. Various systems, such as tracheostomy and the T-piece, deliver oxygen to the lungs, ensuring adequate arterial oxygenation.
Tracheostomy
A tracheostomy is a surgically created opening (stoma) in the anterior part of the trachea. It is used to establish a patient airway, bypass an upper airway obstruction, simplify the removal of secretions, permit long-term...
6.4K
Correlation and Causation01:27

Correlation and Causation

42.9K
Statistical tests can calculate whether there is a relationship, or correlation, between independent and dependent variables. An indirect relationship of the variables signifies a correlation, while a direct relationship shows causation. If it is determined that no connection exists between the variables, then the correlation is a coincidence.
Correlation versus Causation
If the dependent variable increases or decreases when the independent variable increases, there is a positive or negative...
42.9K
Photosystem I01:27

Photosystem I

70.0K
Although structurally similar to photosystem II (PSII), photosystem I (PSI) is has a different electron supplier and electron acceptor.
Both these photosystems work in concert. An excited electron from PSII is relayed to PSI via an electron transport chain in the thylakoid membrane of the chloroplast, which is comprised of the carrier molecule plastoquinone, the dual-protein cytochrome complex, and plastocyanin. As electrons move between PSII and PSI, they lose energy and must be re-energized...
70.0K
Photosystem II01:22

Photosystem II

78.8K
The multi-protein complex photosystem II (PS II) harvests photons and transfers their energy through its bound pigments to its reaction center, and ultimately to photosystem I (PSI) through the electron transport chain. The pigments responsible for caputirng the light energy in photosystems include chlorophyll a, chlorophyll b, and carotenoids.
The pigment molecules are arranged across  two photosystem domains — the antenna complex and the reaction center. The main aim of the pigment...
78.8K
Base Excision Repair01:54

Base Excision Repair

26.4K
One of the common DNA damages is the chemical alteration of single bases by alkylation, oxidation, or deamination. The altered bases cause mispairing and strand breakage during replication. This type of damage causes minimal change to the DNA double helix structure and can be repaired by the base excision repair (BER) pathways. BER corrects damaged DNA sequences by removing the damaged base and restoring the original base sequence using the complementary strand as a template.
The first step of...
26.4K

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Crosstalk Between Viral Envelop-E Protein and Host Innate Immune System: Exploring Pharmacological Targets and Agents.

Reviews in medical virology·2025
Same author

Phytochemical profiling, <i>in silico</i> molecular docking and ADMET prediction of alkaloid rich fraction of <i>Elaeocarpus angustifolius</i> blume seeds against Alzheimer's disease.

Natural product research·2025
Same author

Targeting and engineering biomarkers for prostate cancer therapy.

Molecular aspects of medicine·2025
Same author

Inhibition of the Transforming Growth Factor-β Signaling Pathway Confers Neuroprotective Effects on Beta-Amyloid-Induced Direct Neurotoxicity and Microglia-Mediated Neuroinflammation.

Neurology research international·2025
Same author

Cellular signalling of melatonin and its role in metabolic disorders.

Molecular biology reports·2025
Same author

Oral co-polymeric raft-forming nano gels for targeted empagliflozin delivery against stomach cancer (SGC7901).

Heliyon·2024

Related Experiment Video

Updated: Feb 9, 2026

Activating Autophagy by Aerobic Exercise in Mice
08:44

Activating Autophagy by Aerobic Exercise in Mice

Published on: February 3, 2017

12.8K

Autophagy and GLUT4: The missing pieces.

Safa Abdelgadir Mohamed Elhassan1, Mayuren Candasamy2, Elaine Wan Ling Chan3

  • 1School of Postgraduate Studies, International Medical University, No 126, Jalan Jalil Perkasa 19, Bukit Jalil 57000, Kuala Lumpur, Malaysia.

Diabetes & Metabolic Syndrome
|May 31, 2018
PubMed
Summary

Autophagy, a cellular recycling process, may regulate GLUT4 protein transport. This offers a potential new strategy for managing type 2 diabetes by improving glucose uptake.

Keywords:
AMPKAutophagyGLUT4GolgiPI3K

More Related Videos

Live Images of GLUT4 Protein Trafficking in Mouse Primary Hypothalamic Neurons Using Deconvolution Microscopy
08:47

Live Images of GLUT4 Protein Trafficking in Mouse Primary Hypothalamic Neurons Using Deconvolution Microscopy

Published on: December 7, 2017

10.2K
Live Cell Imaging of Early Autophagy Events: Omegasomes and Beyond
09:00

Live Cell Imaging of Early Autophagy Events: Omegasomes and Beyond

Published on: July 27, 2013

19.2K

Related Experiment Videos

Last Updated: Feb 9, 2026

Activating Autophagy by Aerobic Exercise in Mice
08:44

Activating Autophagy by Aerobic Exercise in Mice

Published on: February 3, 2017

12.8K
Live Images of GLUT4 Protein Trafficking in Mouse Primary Hypothalamic Neurons Using Deconvolution Microscopy
08:47

Live Images of GLUT4 Protein Trafficking in Mouse Primary Hypothalamic Neurons Using Deconvolution Microscopy

Published on: December 7, 2017

10.2K
Live Cell Imaging of Early Autophagy Events: Omegasomes and Beyond
09:00

Live Cell Imaging of Early Autophagy Events: Omegasomes and Beyond

Published on: July 27, 2013

19.2K

Area of Science:

  • Cell Biology
  • Metabolic Diseases

Background:

  • Autophagy degrades cellular components via lysosomes, impacting disease pathophysiology.
  • Autophagy's dual role in type 2 diabetes is recognized, but its specific regulation of GLUT4 trafficking is understudied.
  • Insulin normally drives GLUT4 to the plasma membrane, a process often impaired in type 2 diabetes.

Purpose of the Study:

  • To explore autophagy's potential role in mediating GLUT4 (glucose transporter type 4) trafficking.
  • To investigate how autophagy influences GLUT4 endocytosis, intracellular transport, and cell surface translocation.

Main Methods:

  • Review of existing literature on autophagy and GLUT4 trafficking mechanisms.
  • Analysis of shared molecular machinery, including SNAREs, PI3K, and AMPK, in both processes.

Main Results:

  • Autophagy and GLUT4 share overlapping endocytic pathways and intracellular compartments.
  • Both processes utilize similar exocytic proteins (SNAREs).
  • Key signaling molecules like PI3K and AMPK regulate both autophagy and GLUT4.

Conclusions:

  • Autophagy's control over GLUT4 trafficking presents a promising therapeutic avenue for type 2 diabetes.
  • Targeting autophagy could restore proper glucose transporter function and improve glycemic control.