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PAPP-A and cancer

Cheryl A Conover1, Claus Oxvig2

  • 1From the Division of Endocrinology Mayo ClinicRochester, Minnesota, USA Conover.Cheryl@mayo.edu.

Journal of Molecular Endocrinology
|May 31, 2018
PubMed

The zinc metalloproteinase, PAPP-A, enhances local insulin-like growth factor (IGF) action through cleavage of inhibitory IGF-binding proteins, thereby increasing IGF available for IGF receptor-mediated cell proliferation, migration and survival. In many tumors, enhanced IGF receptor signaling is associated with tumor growth, invasion and metastasis. We will first discuss PAPP-A structure and function, and post-translational inhibitors of PAPP-A expression or proteolytic activity. We will then review the evidence supporting an important role for PAPP-A in many cancers, including breast, ovarian and lung cancer, and Ewing sarcoma.

Keywords:
Ewing sarcomabreast cancerinsulin-like growth factorlung cancermelanomamesotheliomaovarian cancerpregnancy-associated plasma protein-Astanniocalcin

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