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Studying Triple Negative Breast Cancer Using Orthotopic Breast Cancer Model
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PAPP-A and cancer.

Cheryl A Conover1, Claus Oxvig2

  • 1From the Division of Endocrinology Mayo ClinicRochester, Minnesota, USA Conover.Cheryl@mayo.edu.

Journal of Molecular Endocrinology
|May 31, 2018
PubMed
Summary
This summary is machine-generated.

Pregnancy-associated plasma protein-A (PAPP-A) boosts insulin-like growth factor (IGF) activity, promoting cancer cell growth and spread. Inhibiting PAPP-A may offer new cancer treatment strategies.

Keywords:
Ewing sarcomabreast cancerinsulin-like growth factorlung cancermelanomamesotheliomaovarian cancerpregnancy-associated plasma protein-Astanniocalcin

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Area of Science:

  • Biochemistry
  • Molecular Biology
  • Oncology

Background:

  • Pregnancy-associated plasma protein-A (PAPP-A) is a zinc metalloproteinase.
  • PAPP-A cleaves insulin-like growth factor (IGF)-binding proteins, increasing IGF bioavailability.
  • Elevated IGF receptor signaling is linked to tumor progression, invasion, and metastasis.

Purpose of the Study:

  • To review the structure and function of PAPP-A.
  • To discuss post-translational inhibitors of PAPP-A.
  • To summarize the role of PAPP-A in various cancers.

Main Methods:

  • Literature review of PAPP-A structure and function.
  • Analysis of evidence linking PAPP-A to cancer development.
  • Discussion of PAPP-A inhibitors.

Main Results:

  • PAPP-A enhances IGF action, promoting cell proliferation, migration, and survival.
  • PAPP-A plays a significant role in the progression of breast, ovarian, lung cancers, and Ewing sarcoma.
  • Inhibitors of PAPP-A expression or activity are potential therapeutic targets.

Conclusions:

  • PAPP-A is a key mediator of IGF action in cancer.
  • Targeting PAPP-A presents a promising therapeutic strategy for multiple cancer types.
  • Further research into PAPP-A inhibitors is warranted for cancer treatment.