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Updated: Feb 9, 2026

Frequency Mixing Magnetic Detection Scanner for Imaging Magnetic Particles in Planar Samples
Published on: June 9, 2016
Magnetic Detection Structure for Lab-on-Chip Applications Based on the Frequency Mixing Technique
Amine Rabehi1, Benjamin Garlan2, Stefan Achtsnicht3
1Laboratoire d'Electronique et d'Electromagnétisme, Sorbonne Université, L2E, 75252 Paris, France. amine.rabehi@sorbonne-universite.fr.
Abstract:
A magnetic frequency mixing technique with a set of miniaturized planar coils was investigated for use with a completely integrated Lab-on-Chip (LoC) pathogen sensing system. The system allows the detection and quantification of superparamagnetic beads. Additionally, in terms of magnetic nanoparticle characterization ability, the system can be used for immunoassays using the beads as markers. Analytical calculations and simulations for both excitation and pick-up coils are presented; the goal was to investigate the miniaturization of simple and cost-effective planar spiral coils. Following these calculations, a Printed Circuit Board (PCB) prototype was designed, manufactured, and tested for limit of detection, linear response, and validation of theoretical concepts. Using the magnetic frequency mixing technique, a limit of detection of 15 µg/mL of 20 nm core-sized nanoparticles was achieved without any shielding.
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